<1R-(1α,2α,3α)>-2-(hydroxymethyl)-1-(4-morpholinylcarbonyl)-3-phenylcyclopropane

Base Information

• Chemical Name: <1R-(1α,2α,3α)>-2-(hydroxymethyl)-1-(4-morpholinylcarbonyl)-3-phenylcyclopropane
• CAS No.: 141041-95-4
• Molecular Formula: C₁₅H₁₉NO₃
• Molecular Weight: 261.321

Synonyms:<1R-(1α,2α,3α)>-2-(hydroxymethyl)-1-(4-morpholinylcarbonyl)-3-phenylcyclopropane

Chemical Property of <1R-(1α,2α,3α)>-2-(hydroxymethyl)-1-(4-morpholinylcarbonyl)-3-phenylcyclopropane

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Technology Process of <1R-(1α,2α,3α)>-2-(hydroxymethyl)-1-(4-morpholinylcarbonyl)-3-phenylcyclopropane

There total 10 articles about <1R-(1α,2α,3α)>-2-(hydroxymethyl)-1-(4-morpholinylcarbonyl)-3-phenylcyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

morpholine (110-91-8,99108-56-2) + (1R-(1α,5α,6α))-6-phenyl-3-oxabicyclo[3.1.0]hexan-2-one (132435-60-0) → <1R-(1α,2α,3α)>-2-(hydroxymethyl)-1-(4-morpholinylcarbonyl)-3-phenylcyclopropane (141041-95-4)

Guidance literature:

With trimethylaluminum; In dichloromethane; Heating;

DOI:10.1016/0960-894X(96)00407-6

Reference yield: 88.0%

1-(4-morpholinylcarbonyl)-2-(hydroxymethyl)-3-phenylcyclopropane (130780-69-7,141041-95-4,141506-48-1,141506-56-1) → ((1S,2S,3R)-2-Hydroxymethyl-3-phenyl-cyclopropyl)-morpholin-4-yl-methanone (130780-69-7,141041-95-4,141506-48-1,141506-56-1)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; for 1h; Ambient temperature;

DOI:10.1021/jm960059+

Reference yield: 81.0%

C6H14AlNO (130780-74-4) + endo-6-phenyl-3-oxabicyclo<3.1.0>hexan-2-one (88539-24-6,130855-58-2,132435-60-0,132435-61-1,141041-89-6,141506-44-7) → 1-(4-morpholinylcarbonyl)-2-(hydroxymethyl)-3-phenylcyclopropane (130780-69-7,141041-95-4,141506-48-1,141506-56-1)

Guidance literature:

In dichloromethane; at 40 ℃; for 48h;

DOI:10.1016/S0040-4039(00)97718-9

upstream raw materials:

C₆H₁₄AlNO

endo-6-phenyl-3-oxabicyclo<3.1.0>hexan-2-one

morpholine

cis-3-phenyl-2-propen-1-yl diazoacetate

Downstream raw materials:

((1S,2S,3R)-2-Hydroxymethyl-3-phenyl-cyclopropyl)-morpholin-4-yl-methanone

1-(4-morpholinylcarbonyl)-2-formyl-3-phenylcyclopropane

(1S,2S,3S)-2-(Morpholine-4-carbonyl)-3-phenyl-cyclopropanecarboxylic acid

(1R,2R,3R)-2-(Morpholine-4-carbonyl)-3-phenyl-cyclopropanecarboxylic acid

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