C₄₇H₅₁Cl₃N₂O₉Si

Base Information

• Chemical Name: C₄₇H₅₁Cl₃N₂O₉Si
• CAS No.: 886437-95-2
• Molecular Formula: C₄₇H₅₁Cl₃N₂O₉Si
• Molecular Weight: 922.374
• Mol file: 886437-95-2.mol

Synonyms:C₄₇H₅₁Cl₃N₂O₉Si

Chemical Property of C₄₇H₅₁Cl₃N₂O₉Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₇H₅₁Cl₃N₂O₉Si

There total 17 articles about C₄₇H₅₁Cl₃N₂O₉Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

C45H52N2O7Si (886438-09-1) + 2,2,2-Trichloroethyl chloroformate (17341-93-4) → C47H51Cl3N2O9Si (886437-95-2)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; In toluene; at 110 ℃; for 3h;

DOI:10.1002/anie.200503983

Reference yield:

[1-(6-allyloxy-7-methyl-benzo[1,3]dioxol-4-yl)-2-benzyloxy-ethyl]-(2,2-dimethoxy-ethyl)-amine (886437-88-3) → C47H51Cl3N2O9Si (886437-95-2)

Guidance literature:

Multi-step reaction with 9 steps

1: 90 percent / HCl / dioxane / 72 h / 0 - 25 °C

2: 85 percent / bis(2-oxo-3-oxazolidinyl)phosphinic chloride; triethylamine / CH₂Cl₂ / 24 h / 0 - 25 °C

3: 90 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone; buffer solution / CH₂Cl₂ / 0.5 h / 25 °C / pH 7

4: 61 percent / Cu(OTf)2 / benzene / 0.25 h / 85 °C

5: 94 percent / Dess-Martin periodinane / CH₂Cl₂ / 5 h / 25 °C

6: 93 percent / tributyltin hydride; acetic acid / [(PPh₃)2PdCl₂] / 1 h / 0 - 25 °C

7: CHF₂COOH; MgSO₄ / benzene / 0.75 h / 100 °C

8: 100 percent / triethylamine / CH₂Cl₂ / 0.5 h / 0 °C

9: 92 percent / tetrabutylammonium iodide / toluene / 3 h / 110 °C

With hydrogenchloride; Difluoroacetic acid; buffer solution; tri-n-butyl-tin hydride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; tetra-(n-butyl)ammonium iodide; copper(II) bis(trifluoromethanesulfonate); magnesium sulfate; Dess-Martin periodane; acetic acid; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; dichloromethane; toluene; benzene;

DOI:10.1002/anie.200503983

Reference yield:

2-benzyloxy-1-[6-(tert-butyl-diphenyl-silanyloxy)-7-methyl-benzo[1,3]dioxol-4-yl]-ethanone (886437-85-0) → C47H51Cl3N2O9Si (886437-95-2)

Guidance literature:

Multi-step reaction with 13 steps

1.1: HCO₂H; triethylamine / Noyori (R,R)-catalyst / dimethylformamide / 24 h / 0 - 40 °C

1.2: diphenylphosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene; dimethylformamide / 24 h / 50 °C

1.3: H₂ / Pd/C / ethyl acetate / 15 h / 25 °C

2.1: acetic acid; NaCNBH₃; MgSO₄ / methanol / 4 h / 0 - 65 °C

3.1: tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

4.1: 84 percent / NaH / dimethylformamide / 2 h / 0 - 25 °C

5.1: 90 percent / HCl / dioxane / 72 h / 0 - 25 °C

6.1: 85 percent / bis(2-oxo-3-oxazolidinyl)phosphinic chloride; triethylamine / CH₂Cl₂ / 24 h / 0 - 25 °C

7.1: 90 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone; buffer solution / CH₂Cl₂ / 0.5 h / 25 °C / pH 7

8.1: 61 percent / Cu(OTf)2 / benzene / 0.25 h / 85 °C

9.1: 94 percent / Dess-Martin periodinane / CH₂Cl₂ / 5 h / 25 °C

10.1: 93 percent / tributyltin hydride; acetic acid / [(PPh₃)2PdCl₂] / 1 h / 0 - 25 °C

11.1: CHF₂COOH; MgSO₄ / benzene / 0.75 h / 100 °C

12.1: 100 percent / triethylamine / CH₂Cl₂ / 0.5 h / 0 °C

13.1: 92 percent / tetrabutylammonium iodide / toluene / 3 h / 110 °C

With hydrogenchloride; Difluoroacetic acid; formic acid; buffer solution; tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; tetra-(n-butyl)ammonium iodide; copper(II) bis(trifluoromethanesulfonate); sodium hydride; sodium cyanoborohydride; magnesium sulfate; Dess-Martin periodane; acetic acid; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; bis-triphenylphosphine-palladium(II) chloride; ((1R,2R)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine)ruthenium chloride(I) (4-cymene); In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; benzene;

DOI:10.1002/anie.200503983

upstream raw materials:

C₄₅H₅₂N₂O₇Si

2,2,2-Trichloroethyl chloroformate

7-bromo-4-methylbenzo[d][1,3]dioxol-5-ol

(7-bromo-4-methyl-benzo[1,3]dioxol-5-yloxy)-tert-butyl-diphenyl-silane

Downstream raw materials:

C₄₃H₄₁Cl₃N₂O₁₀

C₄₃H₄₁Cl₃N₂O₁₁

C₄₃H₄₃Cl₃N₂O₁₁

C₄₁H₃₇Cl₃N₂O₉