N-benzyl-N-[(9H-fluorene-9-ylmethoxy)carbonyl]-N'-(tert-butoxycarbonyl)hydrazine

Base Information

Chemical Name:N-benzyl-N-[(9H-fluorene-9-ylmethoxy)carbonyl]-N'-(tert-butoxycarbonyl)hydrazine
CAS No.:540483-69-0
Molecular Formula:C₂₇H₂₈N₂O₄
Molecular Weight:444.53
Hs Code.:

Synonyms:N-benzyl-N-[(9H-fluorene-9-ylmethoxy)carbonyl]-N'-(tert-butoxycarbonyl)hydrazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-benzyl-N-[(9H-fluorene-9-ylmethoxy)carbonyl]-N'-(tert-butoxycarbonyl)hydrazine

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Technology Process of N-benzyl-N-[(9H-fluorene-9-ylmethoxy)carbonyl]-N'-(tert-butoxycarbonyl)hydrazine

There total 1 articles about N-benzyl-N-[(9H-fluorene-9-ylmethoxy)carbonyl]-N'-(tert-butoxycarbonyl)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 53370-84-6
N'-benzylhydrazinecarboxylic acid tert-butyl ester

: 540483-69-0
N-benzyl-N-[(9H-fluorene-9-ylmethoxy)carbonyl]-N'-(tert-butoxycarbonyl)hydrazine

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane; at 20 ℃;
DOI:10.1021/jm0210921

Reference yield:

: 540483-69-0
N-benzyl-N-[(9H-fluorene-9-ylmethoxy)carbonyl]-N'-(tert-butoxycarbonyl)hydrazine

: N-benzyl-hydrazinecarboxylic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: With chlorotriisopropylsilane; trifluoroacetic acid; In dichloromethane; for 0.5h;
DOI:10.1021/jm0210921

Reference yield:

: 540483-69-0
N-benzyl-N-[(9H-fluorene-9-ylmethoxy)carbonyl]-N'-(tert-butoxycarbonyl)hydrazine

: N₁-(2-phenylethyl)-(2R)-2-{[N'-(benzyl)hydrazino]carboxamido}-3-(1H-3-indolyl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: triisopropylsilane; TFA / CH₂Cl₂ / 0.5 h

2: DMAP / CH₂Cl₂

3: DMAP / CH₂Cl₂ / 0.5 h / 20 °C

4: 34.2 mg / triisopropylsilane; TFA / CH₂Cl₂ / 0.5 h

With dmap; chlorotriisopropylsilane; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm0210921