9,9,11,11-Tetrachloro-4-(toluene-4-sulfonyl)-4-aza-tricyclo[5.3.1.0^1,7]undecane

Base Information

• Chemical Name: 9,9,11,11-Tetrachloro-4-(toluene-4-sulfonyl)-4-aza-tricyclo[5.3.1.0^1,7]undecane
• CAS No.: 185899-67-6
• Molecular Formula: C₁₇H₁₉Cl₄NO₂S
• Molecular Weight: 443.221
• Mol file: 185899-67-6.mol

Synonyms:9,9,11,11-Tetrachloro-4-(toluene-4-sulfonyl)-4-aza-tricyclo[5.3.1.0^1,7]undecane

Chemical Property of 9,9,11,11-Tetrachloro-4-(toluene-4-sulfonyl)-4-aza-tricyclo[5.3.1.0^1,7]undecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9,9,11,11-Tetrachloro-4-(toluene-4-sulfonyl)-4-aza-tricyclo[5.3.1.0^1,7]undecane

There total 1 articles about 9,9,11,11-Tetrachloro-4-(toluene-4-sulfonyl)-4-aza-tricyclo[5.3.1.0^1,7]undecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloroform (67-66-3,8013-54-5) + 7,7-dichloro-1,2,4,5,6,8-hexahydrocyclopenta[d]azepin-3-yl-p-tolylsulfone (185899-66-5) → 9,9,11,11-Tetrachloro-4-(toluene-4-sulfonyl)-4-aza-tricyclo[5.3.1.01,7]undecane (185899-67-6)

Guidance literature:

With sodium hydroxide; C₁₉H₃₃N(CH₃)3Br; In ethanol; dichloromethane; at 90 ℃; for 18h;

DOI:10.1021/ja9634987

Reference yield:

9,9,11,11-Tetrachloro-4-(toluene-4-sulfonyl)-4-aza-tricyclo[5.3.1.01,7]undecane (185899-67-6) → 8,11-dichloro-N-tosyl-3-aza[5]metacyclophane (185899-68-7)

Guidance literature:

With potassium tert-butylate; In dimethyl sulfoxide; for 2.5h;

DOI:10.1021/ja9634987

Reference yield:

9,9,11,11-Tetrachloro-4-(toluene-4-sulfonyl)-4-aza-tricyclo[5.3.1.01,7]undecane (185899-67-6) → 1,10-Dichloro-6-(toluene-4-sulfonyl)-6-aza-tricyclo[7.3.1.03,10]trideca-2,9(13)-diene-11,11,12,12-tetracarbonitrile

Guidance literature:

Multi-step reaction with 2 steps

1: t-BuOK / dimethylsulfoxide / 2.5 h

2: CDCl₃ / 12 h / Ambient temperature

With potassium tert-butylate; In chloroform-d1; dimethyl sulfoxide;

DOI:10.1021/ja9634987

upstream raw materials:

chloroform

7,7-dichloro-1,2,4,5,6,8-hexahydrocyclopenta[d]azepin-3-yl-p-tolylsulfone

Downstream raw materials:

8,11-dichloro-N-tosyl-3-aza[5]metacyclophane