[3-(1H-benzoimidazol-2-ylsulfanylmethyl)-2-methyl-phenylsulfanyl]-acetic acid

Base Information

Chemical Name:[3-(1H-benzoimidazol-2-ylsulfanylmethyl)-2-methyl-phenylsulfanyl]-acetic acid
CAS No.:339354-74-4
Molecular Formula:C₁₇H₁₆N₂O₂S₂
Molecular Weight:344.458
Hs Code.:

[3-(1<i>H</i>-benzoimidazol-2-ylsulfanylmethyl)-2-methyl-phenylsulfanyl]-acetic acid

Synonyms:[3-(1H-benzoimidazol-2-ylsulfanylmethyl)-2-methyl-phenylsulfanyl]-acetic acid

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Chemical Property of [3-(1H-benzoimidazol-2-ylsulfanylmethyl)-2-methyl-phenylsulfanyl]-acetic acid

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Technology Process of [3-(1H-benzoimidazol-2-ylsulfanylmethyl)-2-methyl-phenylsulfanyl]-acetic acid

There total 5 articles about [3-(1H-benzoimidazol-2-ylsulfanylmethyl)-2-methyl-phenylsulfanyl]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 339354-72-2
methyl 2-({3-[(1H-benzimidazol-2-ylsulfanyl)methyl]-2-methylphenyl}sulfanyl)acetate

: 339354-74-4
[3-(1H-benzoimidazol-2-ylsulfanylmethyl)-2-methyl-phenylsulfanyl]-acetic acid

Guidance literature:: With lithium hydroxide; In methanol; water; for 1h;
DOI:10.1021/jm020868v

Reference yield:

: 52130-17-3
3-amino-2-methylbenzoic acid

: 339354-74-4
[3-(1H-benzoimidazol-2-ylsulfanylmethyl)-2-methyl-phenylsulfanyl]-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: HCl; NaNO₂ / H₂O / 0 °C

1.2: Na₂CO₃ / methanol; H₂O / 0.75 h / 60 - 70 °C / pH 5 - 6

2.1: 5 g / BH₃*THF / 1 h / 0 °C

3.1: thionyl chloride / CH₂Cl₂ / 4 h / 20 °C

4.1: 4.2 g / NaOH / H₂O; methanol / 6 h / 20 °C

5.1: 76 percent / LiOH / methanol; H₂O / 1 h

With hydrogenchloride; lithium hydroxide; sodium hydroxide; thionyl chloride; borane-THF; sodium nitrite; In methanol; dichloromethane; water;
DOI:10.1021/jm020868v

Reference yield:

: 339354-71-1
methyl 2-{[3-(chloromethyl)-2-methylphenyl]sulfanyl}acetate

: 339354-74-4
[3-(1H-benzoimidazol-2-ylsulfanylmethyl)-2-methyl-phenylsulfanyl]-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 4.2 g / NaOH / H₂O; methanol / 6 h / 20 °C

2: 76 percent / LiOH / methanol; H₂O / 1 h

With lithium hydroxide; sodium hydroxide; In methanol; water;
DOI:10.1021/jm020868v