(2-amino-5-{[tert-butyl(dimethyl)silyl]oxy}phenyl)(4-methylphenyl)methanone

Base Information

Chemical Name:(2-amino-5-{[tert-butyl(dimethyl)silyl]oxy}phenyl)(4-methylphenyl)methanone
CAS No.:1330529-96-8
Molecular Formula:C₂₀H₂₇NO₂Si
Molecular Weight:341.525
Hs Code.:

Synonyms:(2-amino-5-{[tert-butyl(dimethyl)silyl]oxy}phenyl)(4-methylphenyl)methanone

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Chemical Property of (2-amino-5-{[tert-butyl(dimethyl)silyl]oxy}phenyl)(4-methylphenyl)methanone

Chemical Property:

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Technology Process of (2-amino-5-{[tert-butyl(dimethyl)silyl]oxy}phenyl)(4-methylphenyl)methanone

There total 5 articles about (2-amino-5-{[tert-butyl(dimethyl)silyl]oxy}phenyl)(4-methylphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 660448-80-6
2-amino-5-{[tert-butyl(dimethyl)silyl]oxy}-N-methoxy-N-methylbenzamide

: 4294-57-9
para-methylphenylmagnesium bromide

: 1330529-96-8
(2-amino-5-{[tert-butyl(dimethyl)silyl]oxy}phenyl)(4-methylphenyl)methanone

Guidance literature:: 2-amino-5-{[tert-butyl(dimethyl)silyl]oxy}-N-methoxy-N-methylbenzamide; para-methylphenylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 0 ℃;

With ammonium chloride; In tetrahydrofuran; diethyl ether; water;
DOI:10.1016/j.bmc.2011.06.032

Reference yield:

: 214957-88-7
2-{[(benzyloxy)carbonyl]amino}-5-hydroxybenzoic acid

: 1330529-96-8
(2-amino-5-{[tert-butyl(dimethyl)silyl]oxy}phenyl)(4-methylphenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 2.5 h / 20 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 14 h / 20 °C

3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 20 h / 20 °C / 760.05 Torr

4: tetrahydrofuran; diethyl ether / 0 °C

With 1H-imidazole; palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.06.032

Reference yield:

: 660448-79-3
benzyl (4-{[tert-butyl(dimethyl)silyl]oxy}-2-{[methoxy(methyl)amino]carbonyl}phenyl)carbamate

: 1330529-96-8
(2-amino-5-{[tert-butyl(dimethyl)silyl]oxy}phenyl)(4-methylphenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 20 h / 20 °C / 760.05 Torr

2: tetrahydrofuran; diethyl ether / 0 °C

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; diethyl ether; ethanol;
DOI:10.1016/j.bmc.2011.06.032