Methanesulfonic acid, trifluoro-, 3-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-4-(4-methylphenyl)-2-(2- methylpropyl)-6-quinolinyl ester

Base Information

Chemical Name:Methanesulfonic acid, trifluoro-, 3-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-4-(4-methylphenyl)-2-(2- methylpropyl)-6-quinolinyl ester
CAS No.:660449-16-1
Molecular Formula:C27H31F3N2O5S
Molecular Weight:552.615
Hs Code.:

Methanesulfonic acid, trifluoro-,
3-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-4-(4-methylphenyl)-2-(2-
methylpropyl)-6-quinolinyl ester

Synonyms:

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Chemical Property of Methanesulfonic acid, trifluoro-, 3-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-4-(4-methylphenyl)-2-(2- methylpropyl)-6-quinolinyl ester

Chemical Property:

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Technology Process of Methanesulfonic acid, trifluoro-, 3-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-4-(4-methylphenyl)-2-(2- methylpropyl)-6-quinolinyl ester

There total 18 articles about Methanesulfonic acid, trifluoro-, 3-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-4-(4-methylphenyl)-2-(2- methylpropyl)-6-quinolinyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 660449-04-7
tert-butyl {[6-hydroxy-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl]methyl}carbamate

: 660449-16-1
3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl trifluoromethanesulfonate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;
DOI:10.1016/j.bmc.2011.06.032

Reference yield: 74.0%

: 660449-04-7
tert-butyl {[6-hydroxy-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl]methyl}carbamate

: 456-64-4
phenyl trifluoromethanesulfonamide

: 660449-16-1
3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl trifluoromethanesulfonate

Guidance literature:: tert-butyl {[6-hydroxy-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl]methyl}carbamate; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 0 ℃; for 0.5h;

phenyl trifluoromethanesulfonamide; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃; for 1h;

Reference yield:

: 660449-03-6
6-hydroxy-4-(4-methylphenyl)-2-(2-methylpropyl)quinoline-3-carbonitrile

: 660449-16-1
3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia; hydrogen / tetrahydrofuran; methanol / 8 h / 70 °C / 3750.38 Torr

2.1: tetrahydrofuran / 3 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

3.2: 0.5 h / 20 °C

With ammonia; hydrogen; sodium hydride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm101236h