2-(4,4-difluoropiperidino)-5-phenyl-7-thiazolo[4,5-b]pyridinecarboxylic acid ethyl ester

Base Information

Chemical Name:2-(4,4-difluoropiperidino)-5-phenyl-7-thiazolo[4,5-b]pyridinecarboxylic acid ethyl ester
CAS No.:1313756-86-3
Molecular Formula:C₂₀H₁₉F₂N₃O₂S
Molecular Weight:403.453
Hs Code.:

Synonyms:2-(4,4-difluoropiperidino)-5-phenyl-7-thiazolo[4,5-b]pyridinecarboxylic acid ethyl ester

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Chemical Property of 2-(4,4-difluoropiperidino)-5-phenyl-7-thiazolo[4,5-b]pyridinecarboxylic acid ethyl ester

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Technology Process of 2-(4,4-difluoropiperidino)-5-phenyl-7-thiazolo[4,5-b]pyridinecarboxylic acid ethyl ester

There total 2 articles about 2-(4,4-difluoropiperidino)-5-phenyl-7-thiazolo[4,5-b]pyridinecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 860344-90-7
4,4-difluoropiperidine-1-carbothioamide

: 6296-54-4
ethyl 2,4-dioxo-4-phenylbutyrate

: 107-14-2
chloroacetonitrile

: 1313756-86-3
2-(4,4-difluoropiperidino)-5-phenyl-7-thiazolo[4,5-b]pyridinecarboxylic acid ethyl ester

Guidance literature:: 4,4-difluoropiperidine-1-carbothioamide; chloroacetonitrile; In methanol; for 1.5h; Heating; Reflux;

ethyl 2,4-dioxo-4-phenylbutyrate; With sodium acetate; acetic acid; for 1.5h; Reflux; Inert atmosphere; Heating;

With sodium hydrogencarbonate; In water;

Reference yield:

: 144230-52-4
4,4-difluoropiperidine hydrochloride

: 1313756-86-3
2-(4,4-difluoropiperidino)-5-phenyl-7-thiazolo[4,5-b]pyridinecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 3 h / 20 °C / Cooling with ice; Inert atmosphere

1.2: 20 °C

2.1: methanol / 1.5 h / Heating; Reflux

2.2: 1.5 h / Reflux; Inert atmosphere; Heating

With triethylamine; In tetrahydrofuran; methanol;

Reference yield:

: 1313756-86-3
2-(4,4-difluoropiperidino)-5-phenyl-7-thiazolo[4,5-b]pyridinecarboxylic acid ethyl ester

: 1313756-67-0
2-(4,4-difluoropiperidino)-5-phenyl-7-thiazolo[4,5-b]pyridinecarboxylic acid

Guidance literature:: 2-(4,4-difluoropiperidino)-5-phenyl-7-thiazolo[4,5-b]pyridinecarboxylic acid ethyl ester; With water; sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 3h;

With ammonium chloride; In 1,4-dioxane; water;