rac-5-(5-bromo-2-fluoro-phenyl)-3-methoxy-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

Base Information

Chemical Name:rac-5-(5-bromo-2-fluoro-phenyl)-3-methoxy-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one
CAS No.:1350523-55-5
Molecular Formula:C₁₃H₁₄BrFN₂O₂
Molecular Weight:329.169
Hs Code.:

Synonyms:rac-5-(5-bromo-2-fluoro-phenyl)-3-methoxy-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

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Chemical Property of rac-5-(5-bromo-2-fluoro-phenyl)-3-methoxy-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

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Technology Process of rac-5-(5-bromo-2-fluoro-phenyl)-3-methoxy-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

There total 11 articles about rac-5-(5-bromo-2-fluoro-phenyl)-3-methoxy-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.4%

: 1350523-55-5
rac-5-(5-bromo-2-fluoro-phenyl)-3-methoxy-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

Guidance literature:: In dichloromethane; at 20 ℃; for 72h;

Reference yield: 73.0%

: 1313525-84-6
rac-5-(5-bromo-2-fluoro-phenyl)-1,5-dimethyl-piperazine-2,3-dione

: 420-37-1
trimethoxonium tetrafluoroborate

: 1350523-55-5
rac-5-(5-bromo-2-fluoro-phenyl)-3-methoxy-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

Guidance literature:: In dichloromethane; at 20 ℃; for 72h;
DOI:10.1016/j.bmcl.2011.10.050

Reference yield:

: 1266784-24-0
(RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propan-1-ol

: 1350523-55-5
rac-5-(5-bromo-2-fluoro-phenyl)-3-methoxy-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydrogencarbonate / tetrahydrofuran / 15 h / 0 °C

2: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C

3: acetic acid / tetrahydrofuran; dichloromethane / 1 h / 20 °C

4: sodium triacetoxy borohydride / 2 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 °C

6: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

7: dichloromethane / 72 h / 20 °C

With sodium triacetoxy borohydride; hydrogenchloride; sodium hydrogencarbonate; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2011.10.050