O-(5'-dimethoxytrityl-thymidin-3'-yl)-O'-(3'-acetylthymidin-5'-yl)hydrogenphosphonate

Base Information

• Chemical Name: O-(5'-dimethoxytrityl-thymidin-3'-yl)-O'-(3'-acetylthymidin-5'-yl)hydrogenphosphonate
• CAS No.: 131326-49-3
• Molecular Formula: C₄₃H₄₇N₄O₁₄P
• Molecular Weight: 874.838
• Mol file: 131326-49-3.mol

Synonyms:O-(5'-dimethoxytrityl-thymidin-3'-yl)-O'-(3'-acetylthymidin-5'-yl)hydrogenphosphonate

Chemical Property of O-(5'-dimethoxytrityl-thymidin-3'-yl)-O'-(3'-acetylthymidin-5'-yl)hydrogenphosphonate

Chemical Property:

Purity/Quality:

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Technology Process of O-(5'-dimethoxytrityl-thymidin-3'-yl)-O'-(3'-acetylthymidin-5'-yl)hydrogenphosphonate

There total 1 articles about O-(5'-dimethoxytrityl-thymidin-3'-yl)-O'-(3'-acetylthymidin-5'-yl)hydrogenphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3'-O-acetylthymidine (21090-30-2) + triethylammonium 5'-O-dimethoxytritylthymidine 3'-H-phosphonate (3868-27-7) → O-(5'-dimethoxytrityl-thymidin-3'-yl)-O'-(3'-acetylthymidin-5'-yl)hydrogenphosphonate (131326-49-3)

Guidance literature:

With pivaloyl chloride; In pyridine; at 20 ℃; for 0.25h;

DOI:10.1016/S0968-0896(02)00615-6

Reference yield:

O-(5'-dimethoxytrityl-thymidin-3'-yl)-O'-(3'-acetylthymidin-5'-yl)hydrogenphosphonate (131326-49-3) → C43H46N4O15P(1-)

Guidance literature:

With 4-methyl-morpholine; pyridine; tetrachloromethane; In [D₃]acetonitrile; water; acetonitrile; at 20 ℃; for 0.0833333h;

DOI:10.1016/S0968-0896(02)00615-6

Reference yield:

L-alanine methyl ester hydrochloride (2491-20-5) + O-(5'-dimethoxytrityl-thymidin-3'-yl)-O'-(3'-acetylthymidin-5'-yl)hydrogenphosphonate (131326-49-3) → C47H54N5O16P

Guidance literature:

With triethylamine; In water; acetonitrile; at 20 ℃; for 0.333333h;

DOI:10.1081/NCN-120018623

upstream raw materials:

3'-O-acetylthymidine

triethylammonium 5'-O-dimethoxytritylthymidine 3'-H-phosphonate