Technology Process of (4R,7R)-4,7-Dibenzyl-[1,3,2]dioxathiepane 2,2-dioxide
There total 6 articles about (4R,7R)-4,7-Dibenzyl-[1,3,2]dioxathiepane 2,2-dioxide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2R,5R)-1,6-diphenylhexane-2,5-diol;
With
thionyl chloride; triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 1.66667h;
With
ruthenium trichloride; sodium periodate;
In
tetrachloromethane; water; acetonitrile;
at 20 ℃;
for 1h;
DOI:10.1021/ol034706k
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: PBr3 / diethyl ether / 0.42 h / 0 - 20 °C
2.1: 61.2 g / Zn; I2 / diethyl ether / -40 - -30 °C
3.1: 97 percent / (DHDQ)2PHAL; K2OsO4*2H2O; K2CO3 / methanesulfonamide; K3Fe(CN)6 / H2O; 2-methyl-propan-2-ol; hexane / 64 h
4.1: Et3N / CH2Cl2 / -50 - 20 °C
5.1: 17.68 g / H2 / Raney-Ni / ethanol; acetone / 760 Torr
6.1: SOCl2; Et3N / CH2Cl2 / 1.67 h / 0 - 20 °C
6.2: 84 percent / NaIO4; RuCl3 / acetonitrile; CCl4; H2O / 1 h / 20 °C
With
potassium osmate(VI); thionyl chloride; hydrogen; iodine; phosphorus tribromide; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine; zinc;
methanesulfonamide; nickel; potassium hexacyanoferrate(III);
In
diethyl ether; ethanol; hexane; dichloromethane; water; acetone; tert-butyl alcohol;
3.1: Sharpless asymmetric dihydroxylation;
DOI:10.1021/ol034706k
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 97 percent / (DHDQ)2PHAL; K2OsO4*2H2O; K2CO3 / methanesulfonamide; K3Fe(CN)6 / H2O; 2-methyl-propan-2-ol; hexane / 64 h
2.1: Et3N / CH2Cl2 / -50 - 20 °C
3.1: 17.68 g / H2 / Raney-Ni / ethanol; acetone / 760 Torr
4.1: SOCl2; Et3N / CH2Cl2 / 1.67 h / 0 - 20 °C
4.2: 84 percent / NaIO4; RuCl3 / acetonitrile; CCl4; H2O / 1 h / 20 °C
With
potassium osmate(VI); thionyl chloride; hydrogen; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine;
methanesulfonamide; nickel; potassium hexacyanoferrate(III);
In
ethanol; hexane; dichloromethane; water; acetone; tert-butyl alcohol;
1.1: Sharpless asymmetric dihydroxylation;
DOI:10.1021/ol034706k
