2-FLUOROMETHYL-PYRIDINE

Base Information

• Chemical Name: 2-FLUOROMETHYL-PYRIDINE
• CAS No.: 173974-87-3
• Molecular Formula: C₆H₆FN
• Molecular Weight: 111.119
• Mol file: 173974-87-3.mol

Synonyms:2-Fluoromethylpyridine

Chemical Property of 2-FLUOROMETHYL-PYRIDINE

Chemical Property:

• PSA: 12.89000
• LogP: 1.55110

Purity/Quality:

97% ^*data from raw suppliers

2-FLUOROMETHYL-PYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-FLUOROMETHYL-PYRIDINE

There total 5 articles about 2-FLUOROMETHYL-PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2-(trifluoromethyl)pyridine (368-48-9) → 2-(difluoromethyl)pyridine (114468-01-8) + 2-(fluoromethyl)pyridine (173974-87-3)

Guidance literature:

With 3,7-di([1,1′-biphenyl]-4-yl)-10-(naphthalen-1-yl)-10H-phenoxazine; cesium formate; In dimethyl sulfoxide; at 23 ℃; for 24h; Schlenk technique; Inert atmosphere; Irradiation; Sealed tube;

DOI:10.1021/jacs.9b06004

Reference yield: 41.0%

→ 2-(fluoromethyl)pyridine (173974-87-3)

Guidance literature:

With potassium fluoride; formic acid; tetramethylammonium fluoride; N,N`-sulfuryldiimidazole; In N,N-dimethyl-formamide; at 20 ℃; for 4h; Inert atmosphere;

Reference yield: 12.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + pyridine (110-86-1) + 1-isocyano-4-(trifluoromethyl)benzene (139032-23-8) → N-(4-trifluorophenyl)-2-pyridinecarboxamide + 2-[3-(4-trifluoromethyl-phenyl)-3H-[1,2,3]triazol-4-yl]-pyridine + 2-(fluoromethyl)pyridine (173974-87-3)

Guidance literature:

pyridine; With fluorine; In chloroform; at -78 - -60 ℃;

diazomethane; 1-isocyano-4-(trifluoromethyl)benzene; In chloroform; at -60 - 20 ℃;

DOI:10.1016/j.tetlet.2006.02.030

upstream raw materials:

α-picoline

2-chloromethylpyridine

diazomethane

pyridine

Refernces

• 1、 -. "PROCESSES FOR FLUORINATION". Paragraph 0179; 0184; 0214-0215; 0224. . Retrieved 2021/04/10.
• 2、 Vogt, David B.,Seath, Ciaran P.,Wang, Hengbin,Jui, Nathan T.. "Selective C-F Functionalization of Unactivated Trifluoromethylarenes". supporting information. p. 13203 - 13211. Retrieved 2019/09/03.