Pyridine, 2-(difluoromethyl)- (9CI)

Base Information

• Chemical Name: Pyridine, 2-(difluoromethyl)- (9CI)
• CAS No.: 114468-01-8
• Molecular Formula: C6H5 F2 N
• Molecular Weight: 129.109
• Hs Code.: 2933399090
• Mol file: 114468-01-8.mol

Synonyms:Pyridine, 2-(difluoromethyl)- (9CI)

Chemical Property of Pyridine, 2-(difluoromethyl)- (9CI)

Chemical Property:

• Boiling Point: 58℃/30mm
• Flash Point: 41°(106°F)
• PSA: 12.89000
• Density: 1.204
• LogP: 2.01920
• Solubility.: soluble1.454 at 20°C

Purity/Quality:

97% ^*data from raw suppliers

2-(Difluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 10-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyridine, 2-(difluoromethyl)- (9CI)

There total 10 articles about Pyridine, 2-(difluoromethyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

pyridine-2-carbaldehyde (1121-60-4) → 2-(difluoromethyl)pyridine (114468-01-8)

Guidance literature:

With potassium fluoride; formic acid; tetramethylammonium fluoride; N,N`-sulfuryldiimidazole; In N,N-dimethyl-formamide; at 25 ℃; for 4h; Reagent/catalyst; Inert atmosphere;

DOI:10.1021/acs.orglett.9b00054

Reference yield: 60.0%

2-iodopyridine (5029-67-4) + tributyl(difluoromethyl)stannane (1438388-96-5) → 2-(difluoromethyl)pyridine (114468-01-8)

Guidance literature:

With potassium fluoride; copper(l) iodide; In N,N-dimethyl acetamide; at 100 ℃; for 24h; Inert atmosphere; Glovebox; Darkness;

DOI:10.1002/anie.201205850

Reference yield: 58.0%

2-(trifluoromethyl)pyridine (368-48-9) → 2-(difluoromethyl)pyridine (114468-01-8) + 2-(fluoromethyl)pyridine (173974-87-3)

Guidance literature:

With 3,7-di([1,1′-biphenyl]-4-yl)-10-(naphthalen-1-yl)-10H-phenoxazine; cesium formate; In dimethyl sulfoxide; at 23 ℃; for 24h; Schlenk technique; Inert atmosphere; Irradiation; Sealed tube;

DOI:10.1021/jacs.9b06004

upstream raw materials:

pyridine-2-carbaldehyde

2-iodopyridine

tributyl(difluoromethyl)stannane

pyridine