2-[3'-(4''-chlorophenyl)-4',6'-dimethoxyindol-2'-yl]glyoxyloyl chloride

Base Information

• Chemical Name: 2-[3'-(4''-chlorophenyl)-4',6'-dimethoxyindol-2'-yl]glyoxyloyl chloride
• CAS No.: 180859-27-2
• Molecular Formula: C₁₈H₁₃Cl₂NO₄
• Molecular Weight: 378.212

Synonyms:2-[3'-(4''-chlorophenyl)-4',6'-dimethoxyindol-2'-yl]glyoxyloyl chloride

Chemical Property of 2-[3'-(4''-chlorophenyl)-4',6'-dimethoxyindol-2'-yl]glyoxyloyl chloride

Chemical Property:

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Technology Process of 2-[3'-(4''-chlorophenyl)-4',6'-dimethoxyindol-2'-yl]glyoxyloyl chloride

There total 2 articles about 2-[3'-(4''-chlorophenyl)-4',6'-dimethoxyindol-2'-yl]glyoxyloyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

oxalyl dichloride (79-37-8) + 3-(4-chlorophenyl)-4,6-dimethoxy-1H-indole (151290-21-0) → 2-[3'-(4''-chlorophenyl)-4',6'-dimethoxyindol-2'-yl]glyoxyloyl chloride (180859-27-2) + 3-(4-chlorophenyl)-4,6-dimethoxy-1H-indol-7-yl-glyoxyloylchloride

Guidance literature:

In diethyl ether; at 0 - 20 ℃; for 3h;

DOI:10.1039/c4ob00460d

Reference yield:

oxalyl dichloride (79-37-8) + 3-(4-chlorophenyl)-4,6-dimethoxy-1H-indole (151290-21-0) → 2-[3'-(4''-chlorophenyl)-4',6'-dimethoxyindol-2'-yl]glyoxyloyl chloride (180859-27-2)

Guidance literature:

In diethyl ether; at 0 - 20 ℃; for 3h;

DOI:10.1016/j.bmc.2015.02.037

Reference yield: 82.0%

morpholine (110-91-8,99108-56-2) + 2-[3'-(4''-chlorophenyl)-4',6'-dimethoxyindol-2'-yl]glyoxyloyl chloride (180859-27-2) → 1-(3-(4-chlorophenyl)-4,6-dimethoxy-1H-indol-2-yl)-2-(morpholin-4-yl)ethane-1,2-dione

Guidance literature:

In diethyl ether; at 20 ℃;

DOI:10.1016/j.bmc.2015.02.037

upstream raw materials:

oxalyl dichloride

3-(4-chlorophenyl)-4,6-dimethoxy-1H-indole

Downstream raw materials:

1-[3-(4-Chloro-phenyl)-4,6-dimethoxy-1H-indol-2-yl]-2-pyrrolidin-1-yl-ethane-1,2-dione

2-[3-(4-Chloro-phenyl)-4,6-dimethoxy-1H-indol-2-yl]-N,N-dimethyl-2-oxo-acetamide

N-t-butyl-2-(3'-(4''-chlorophenyl)-4',6'-dimethoxyindol-2'-yl)glyoxylamide

N-methyl-2-(3'-(4''-chlorophenyl)-4',6'-dimethoxyindol-2'-yl)glyoxylamide

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