5-chloro-thiophene-2-carboxylic acid ((3R,4S)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-4-hydroxymethyl-pyrrolidin-3-yl)-amide

Base Information

• Chemical Name: 5-chloro-thiophene-2-carboxylic acid ((3R,4S)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-4-hydroxymethyl-pyrrolidin-3-yl)-amide
• CAS No.: 913743-22-3
• Molecular Formula: C₂₃H₂₂ClFN₄O₄S
• Molecular Weight: 504.969

Synonyms:5-chloro-thiophene-2-carboxylic acid ((3R,4S)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-4-hydroxymethyl-pyrrolidin-3-yl)-amide

Chemical Property of 5-chloro-thiophene-2-carboxylic acid ((3R,4S)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-4-hydroxymethyl-pyrrolidin-3-yl)-amide

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Technology Process of 5-chloro-thiophene-2-carboxylic acid ((3R,4S)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-4-hydroxymethyl-pyrrolidin-3-yl)-amide

There total 1 articles about 5-chloro-thiophene-2-carboxylic acid ((3R,4S)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-4-hydroxymethyl-pyrrolidin-3-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3S,4R)-4-[(5-chloro-thiophene-2-carbonyl)-amino]-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl-carbamoyl]-methyl}-pyrrolidine-3-carboxylic acid ethyl ester (913743-18-7) → 5-chloro-thiophene-2-carboxylic acid ((3R,4S)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-4-hydroxymethyl-pyrrolidin-3-yl)-amide (913743-22-3)

Guidance literature:

With sodium tetrahydroborate; ethanol; at 20 ℃;

DOI:10.1016/j.ejmech.2008.12.025

Reference yield:

5-chloro-thiophene-2-carboxylic acid ((3R,4S)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-4-hydroxymethyl-pyrrolidin-3-yl)-amide (913743-22-3) + methanesulfonyl chloride (124-63-0) → methanesulfonic acid (3S,4R)-4-[(5-chloro-thiophene-2-carbonyl)-amino]-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-pyrrolidin-3-ylmethyl ester (913743-23-4)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 25 ℃; for 49h;

upstream raw materials:

(3S,4R)-4-[(5-chloro-thiophene-2-carbonyl)-amino]-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl-carbamoyl]-methyl}-pyrrolidine-3-carboxylic acid ethyl ester

Downstream raw materials:

methanesulfonic acid (3S,4R)-4-[(5-chloro-thiophene-2-carbonyl)-amino]-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-pyrrolidin-3-ylmethyl ester

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