methanesulfonic acid (3S,4R)-4-[(5-chloro-thiophene-2-carbonyl)-amino]-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-pyrrolidin-3-ylmethyl ester

Base Information

• Chemical Name: methanesulfonic acid (3S,4R)-4-[(5-chloro-thiophene-2-carbonyl)-amino]-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-pyrrolidin-3-ylmethyl ester
• CAS No.: 913743-23-4
• Molecular Formula: C₂₄H₂₄ClFN₄O₆S₂
• Molecular Weight: 583.061

Synonyms:methanesulfonic acid (3S,4R)-4-[(5-chloro-thiophene-2-carbonyl)-amino]-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-pyrrolidin-3-ylmethyl ester

Chemical Property of methanesulfonic acid (3S,4R)-4-[(5-chloro-thiophene-2-carbonyl)-amino]-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-pyrrolidin-3-ylmethyl ester

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Technology Process of methanesulfonic acid (3S,4R)-4-[(5-chloro-thiophene-2-carbonyl)-amino]-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-pyrrolidin-3-ylmethyl ester

There total 1 articles about methanesulfonic acid (3S,4R)-4-[(5-chloro-thiophene-2-carbonyl)-amino]-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-pyrrolidin-3-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-thiophene-2-carboxylic acid ((3R,4S)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-4-hydroxymethyl-pyrrolidin-3-yl)-amide (913743-22-3) + methanesulfonyl chloride (124-63-0) → methanesulfonic acid (3S,4R)-4-[(5-chloro-thiophene-2-carbonyl)-amino]-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-pyrrolidin-3-ylmethyl ester (913743-23-4)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 25 ℃; for 49h;

Reference yield:

azetidine (503-29-7) + methanesulfonic acid (3S,4R)-4-[(5-chloro-thiophene-2-carbonyl)-amino]-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-pyrrolidin-3-ylmethyl ester (913743-23-4) → 5-chloro-thiophene-2-carboxylic acid ((3R,4S)-4-azetidin-1-ylmethyl-1-([2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl)-pyrrolidin-3-yl)amide diformiate

Guidance literature:

In N,N-dimethyl-formamide; at 25 ℃; for 72h;

upstream raw materials:

5-chloro-thiophene-2-carboxylic acid ((3R,4S)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-4-hydroxymethyl-pyrrolidin-3-yl)-amide

methanesulfonyl chloride

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