(3R)-3-methyl-4-(methylsulfanyl)-4-(phenylsulfonyl)butan-1-ol tert-butyldimethylsilyl ether

Base Information

Chemical Name:(3R)-3-methyl-4-(methylsulfanyl)-4-(phenylsulfonyl)butan-1-ol tert-butyldimethylsilyl ether
CAS No.:1331743-69-1
Molecular Formula:C₁₈H₃₂O₃S₂Si
Molecular Weight:388.668
Hs Code.:

Synonyms:(3R)-3-methyl-4-(methylsulfanyl)-4-(phenylsulfonyl)butan-1-ol tert-butyldimethylsilyl ether

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Chemical Property of (3R)-3-methyl-4-(methylsulfanyl)-4-(phenylsulfonyl)butan-1-ol tert-butyldimethylsilyl ether

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Technology Process of (3R)-3-methyl-4-(methylsulfanyl)-4-(phenylsulfonyl)butan-1-ol tert-butyldimethylsilyl ether

There total 5 articles about (3R)-3-methyl-4-(methylsulfanyl)-4-(phenylsulfonyl)butan-1-ol tert-butyldimethylsilyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 2949-92-0,31761-75-8
methanethiosulfonic acid S-methyl ester

: 1331743-67-9
(R)-3-methyl-4-(phenylsulfonyl)butan-1-ol tert-butyldimethylsilyl ether

: 1331743-69-1
(3R)-3-methyl-4-(methylsulfanyl)-4-(phenylsulfonyl)butan-1-ol tert-butyldimethylsilyl ether

Guidance literature:: (R)-3-methyl-4-(phenylsulfonyl)butan-1-ol tert-butyldimethylsilyl ether; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

methanethiosulfonic acid S-methyl ester; In tetrahydrofuran; hexane; at -78 ℃; for 24h; Inert atmosphere;
DOI:10.1039/c1cc13232f

Reference yield:

: 1201829-81-3
(R)-3-methyl-4,4-bis(phenylsulfonyl)butanal

: 1331743-69-1
(3R)-3-methyl-4-(methylsulfanyl)-4-(phenylsulfonyl)butan-1-ol tert-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / methanol / 2 h / 0 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

3.1: samarium diiodide / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

4.2: 24 h / -78 °C / Inert atmosphere

With 1H-imidazole; sodium tetrahydroborate; n-butyllithium; samarium diiodide; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide;
DOI:10.1039/c1cc13232f

Reference yield:

: 1331743-65-7
(R)-3-methyl-4,4-bis(phenylsulfonyl)butan-1-ol tert-butyldimethylsilyl ether

: 1331743-69-1
(3R)-3-methyl-4-(methylsulfanyl)-4-(phenylsulfonyl)butan-1-ol tert-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 2 steps

1.1: samarium diiodide / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 24 h / -78 °C / Inert atmosphere

With n-butyllithium; samarium diiodide; In tetrahydrofuran; hexane;
DOI:10.1039/c1cc13232f