(R)-3-methyl-4,4-bis(phenylsulfonyl)butan-1-ol tert-butyldimethylsilyl ether

Base Information

Chemical Name:(R)-3-methyl-4,4-bis(phenylsulfonyl)butan-1-ol tert-butyldimethylsilyl ether
CAS No.:1331743-65-7
Molecular Formula:C₂₃H₃₄O₅S₂Si
Molecular Weight:482.737
Hs Code.:

Synonyms:(R)-3-methyl-4,4-bis(phenylsulfonyl)butan-1-ol tert-butyldimethylsilyl ether

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Chemical Property of (R)-3-methyl-4,4-bis(phenylsulfonyl)butan-1-ol tert-butyldimethylsilyl ether

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Technology Process of (R)-3-methyl-4,4-bis(phenylsulfonyl)butan-1-ol tert-butyldimethylsilyl ether

There total 3 articles about (R)-3-methyl-4,4-bis(phenylsulfonyl)butan-1-ol tert-butyldimethylsilyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1186231-90-2
(R)-3-methyl-4,4-bis(phenylsulfonyl)butan-1-ol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1331743-65-7
(R)-3-methyl-4,4-bis(phenylsulfonyl)butan-1-ol tert-butyldimethylsilyl ether

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1039/c1cc13232f

Reference yield:

: 1201829-81-3
(R)-3-methyl-4,4-bis(phenylsulfonyl)butanal

: 1331743-65-7
(R)-3-methyl-4,4-bis(phenylsulfonyl)butan-1-ol tert-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 2 h / 0 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

With 1H-imidazole; sodium tetrahydroborate; In methanol; N,N-dimethyl-formamide;
DOI:10.1039/c1cc13232f

Reference yield:

: 3406-02-8
bis(phenylsulfonyl)methane

: 1331743-65-7
(R)-3-methyl-4,4-bis(phenylsulfonyl)butan-1-ol tert-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 3 steps

1: (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine / toluene / 24 h / 0 °C

2: sodium tetrahydroborate / methanol / 2 h / 0 °C

3: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

With (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; 1H-imidazole; sodium tetrahydroborate; In methanol; N,N-dimethyl-formamide; toluene; 1: Michael condensation;
DOI:10.1039/c1cc13232f