3,4-Dichloro-L-Phenylalanine Methyl ester

Base Information

• Chemical Name: 3,4-Dichloro-L-Phenylalanine Methyl ester
• CAS No.: 173522-95-7
• Molecular Formula: C10H11 Cl2 N O2 . Cl H
• Molecular Weight: 284.57
• Mol file: 173522-95-7.mol

Synonyms:3,4-Dichloro-L-Phenylalanine Methyl ester

Chemical Property of 3,4-Dichloro-L-Phenylalanine Methyl ester

Chemical Property:

• PSA: 52.32000
• LogP: 2.73650
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98.5% ^*data from raw suppliers

3,4-Dichloro-phe-omeHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-Dichloro-L-Phenylalanine Methyl ester

There total 2 articles about 3,4-Dichloro-L-Phenylalanine Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Nα-[(tert-butoxy)carbonyl]-3,4-dichloro-L-phenylalanine (114873-13-1,80741-39-5) → (S)-2-amino-3-(3,4-dichloro-phenyl)-propionic acid methyl ester hydrochloride (173522-95-7)

Guidance literature:

With thionyl chloride; In methanol; at 0 - 20 ℃;

Reference yield:

methanol (67-56-1) + (S)-2-amino-3-(3,4-dichlorophenyl)propanoic acid (52794-99-7) → (S)-2-amino-3-(3,4-dichloro-phenyl)-propionic acid methyl ester hydrochloride (173522-95-7)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃;

DOI:10.1021/acs.orglett.9b02819

Reference yield: 50.0%

(S)-2-amino-3-(3,4-dichloro-phenyl)-propionic acid methyl ester hydrochloride (173522-95-7) + 4-iodo-2-nitro benzoic acid (116529-62-5) → (S)-2-(2-nitro-4-iodo-benzoylamino)-3-(3,4-dichloro-phenyl)-propionic acid methyl ester

Guidance literature:

4-iodo-2-nitro benzoic acid; With thionyl chloride; for 2h; Heating / reflux;

(S)-2-amino-3-(3,4-dichloro-phenyl)-propionic acid methyl ester hydrochloride; With dmap; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

N^α-[(tert-butoxy)carbonyl]-3,4-dichloro-L-phenylalanine

methanol

(S)-2-amino-3-(3,4-dichlorophenyl)propanoic acid

Refernces

• 1、 -. "SULFONAMIDE COMPOUNDS". Page/Page column 18. . Retrieved 2010/10/20.