3-methyl-1-[(3S)-2-oxooxolan-3-yl]-3-{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}urea

Base Information

Chemical Name:3-methyl-1-[(3S)-2-oxooxolan-3-yl]-3-{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}urea
CAS No.:1004316-93-1
Molecular Formula:C₁₃H₁₉N₃O₃S
Molecular Weight:297.378
Hs Code.:
Mol file:1004316-93-1.mol

Synonyms:3-methyl-1-[(3S)-2-oxooxolan-3-yl]-3-{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}urea

Suppliers and Price of 3-methyl-1-[(3S)-2-oxooxolan-3-yl]-3-{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}urea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

AK Scientific
1-Methyl-3-(2-oxooxolan-3-yl)-1-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]urea
1g
$ 1133.00

Total 4 raw suppliers

Chemical Property of 3-methyl-1-[(3S)-2-oxooxolan-3-yl]-3-{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}urea

Chemical Property:

Boiling Point:564.2±50.0 °C(Predicted)
PKA:12.30±0.20(Predicted)
Density:1.27±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

1-Methyl-3-(2-oxooxolan-3-yl)-1-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]urea ^*data from reagent suppliers

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Technology Process of 3-methyl-1-[(3S)-2-oxooxolan-3-yl]-3-{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}urea

There total 6 articles about 3-methyl-1-[(3S)-2-oxooxolan-3-yl]-3-{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 6305-38-0,15295-77-9,67580-93-2,110045-70-0
(S)-(-)-α-amino-γ-butyrolactone hydrobromide

: 530-62-1
1,1'-carbonyldiimidazole

: 154212-60-9
N-methyl-N-<(2-isopropyl-4-thiazolyl)methyl>amine

: 1004316-93-1
3-methyl-1-[(3S)-2-oxooxolan-3-yl]-3-{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}urea

Guidance literature:: (S)-(-)-α-amino-γ-butyrolactone hydrobromide; With N-ethyl-N,N-diisopropylamine; In dichloromethane; Industry scale;

1,1'-carbonyldiimidazole; In dichloromethane; at 10 - 25 ℃; Industry scale;

N-methyl-N-<(2-isopropyl-4-thiazolyl)methyl>amine; In dichloromethane; at 25 ℃; Industry scale;

Reference yield: 85.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 2-isopropyl-4-(((N-methyl)amino)methyl)thiazole dihydrochloride

: 2185-02-6
L-homoserine lactone

: 1004316-93-1
3-methyl-1-[(3S)-2-oxooxolan-3-yl]-3-{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}urea

Guidance literature:: bis(trichloromethyl) carbonate; L-homoserine lactone; With sodium hydrogencarbonate; In dichloromethane; at 25 - 35 ℃; for 2.5h; Inert atmosphere;

2-isopropyl-4-(((N-methyl)amino)methyl)thiazole dihydrochloride; In dichloromethane; at 35 ℃; for 1h; Temperature; Concentration; Solvent; Reagent/catalyst;

Reference yield:

: 6305-38-0,15295-77-9,67580-93-2,110045-70-0
(S)-(-)-α-amino-γ-butyrolactone hydrobromide

: 154212-60-9
N-methyl-N-<(2-isopropyl-4-thiazolyl)methyl>amine

: 1004316-93-1
3-methyl-1-[(3S)-2-oxooxolan-3-yl]-3-{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}urea

Guidance literature:: (S)-(-)-α-amino-γ-butyrolactone hydrobromide; 1,1'-carbonyldiimidazole; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 6h;

N-methyl-N-<(2-isopropyl-4-thiazolyl)methyl>amine; In dichloromethane; for 10h;