(S)-ethyl-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanoate oxalate

Base Information

• Chemical Name: (S)-ethyl-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanoate oxalate
• CAS No.: 1247119-36-3
• Molecular Formula: C₂H₂O₄*C₁₉H₃₂N₄O₄S
• Molecular Weight: 502.589
• Mol file: 1247119-36-3.mol

Synonyms:(S)-ethyl-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanoate oxalate

Chemical Property of (S)-ethyl-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanoate oxalate

Chemical Property:

• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99.9% ^*data from raw suppliers

(S)-Ethyl2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanoateoxalate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-ethyl-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanoate oxalate

There total 3 articles about (S)-ethyl-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanoate oxalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

morpholine (110-91-8,99108-56-2) + 3-methyl-1-[(3S)-2-oxooxolan-3-yl]-3-{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}urea (1004316-93-1) + ethanol (64-17-5) + oxalic acid (144-62-7,97993-78-7) → (S)-ethyl-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanoate oxalate (1247119-36-3)

Guidance literature:

3-methyl-1-[(3S)-2-oxooxolan-3-yl]-3-{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}urea; ethanol; With trimethylsilyl bromide; In dichloromethane; at 0 - 25 ℃;

morpholine; In dichloromethane; at 0 - 25 ℃; for 17h;

oxalic acid; In water; acetone; for 1h; Reflux;

Reference yield:

morpholine (110-91-8,99108-56-2) + C15H24IN3O3S (1051461-77-8) + oxalic acid (144-62-7,97993-78-7) → (S)-ethyl-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanoate oxalate (1247119-36-3)

Guidance literature:

morpholine; C₁₅H₂₄IN₃O₃S; In dichloromethane; at 10 - 22 ℃; Industry scale;

oxalic acid; In acetone; for 1h; Reflux; Industry scale;

Reference yield:

2-isopropyl-4-(((N-methyl)amino)methyl)thiazole dihydrochloride → (S)-ethyl-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanoate oxalate (1247119-36-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / -8 - -5 °C

1.2: 15 h / 20 - 25 °C

2.1: trimethylsilyl bromide / dichloromethane / 0 - 25 °C

2.2: 17 h / 0 - 25 °C

2.3: 1 h / Reflux

With trimethylsilyl bromide; triethylamine; In dichloromethane;

upstream raw materials:

morpholine

C₁₅H₂₄IN₃O₃S

oxalic acid

3-methyl-1-[(3S)-2-oxooxolan-3-yl]-3-{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}urea

Downstream raw materials:

C₁₇H₂₇N₄O₄S^(1-)*K⁽¹⁺⁾

Refernces

• 1、 -. "PREPARATION OF COBICISTAT INTERMEDIATES". . . Retrieved 2015/06/18.