1-(ethyloxycarbonyloxy)ethyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride

Base Information

• Chemical Name: 1-(ethyloxycarbonyloxy)ethyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride
• CAS No.: 100165-48-8
• Molecular Formula: C₁₃H₂₃NO₅*ClH
• Molecular Weight: 309.79
• Mol file: 100165-48-8.mol

Synonyms:1-(ethyloxycarbonyloxy)ethyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride

Chemical Property of 1-(ethyloxycarbonyloxy)ethyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-(ethyloxycarbonyloxy)ethyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride

There total 5 articles about 1-(ethyloxycarbonyloxy)ethyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Chloroethyl ethyl carbonate (50893-36-2) + 4-(N-tert-butyloxycarbonylaminomethyl)-cyclohexane-1-carboxylic acid (162046-58-4) → 1-(ethyloxycarbonyloxy)ethyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride (100165-48-8)

Guidance literature:

With hydrogenchloride; tetra(n-butyl)ammonium hydrogen sulfate; In sodium hydroxide; Trichloroethylene; ethyl acetate;

Reference yield:

4-(tert-Butoxycarbonylamino-methyl)-cyclohexanecarboxylic acid 1-ethoxycarbonyloxy-ethyl ester → 1-(ethyloxycarbonyloxy)ethyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride (100165-48-8)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 0 ℃; for 3h; Yield given;

DOI:10.1021/jm00154a004

Reference yield:

trans-4-aminomethyl-cyclohexyl-carboxylic acid (1197-18-8) → 1-(ethyloxycarbonyloxy)ethyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride (100165-48-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / NaOH / H₂O; 2-methyl-propan-2-ol / 18 h / Ambient temperature

2: 1.) tetrabutylammonium hydrogen sulfate (QHSO₄), 2 M aq. NaOH / 2.) trichloroethylene, reflux, 3 h

3: HCl(g) / ethyl acetate / 3 h / 0 °C

With hydrogenchloride; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In water; ethyl acetate; tert-butyl alcohol;

DOI:10.1021/jm00154a004

upstream raw materials:

trans-4-aminomethyl-cyclohexyl-carboxylic acid

trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid

1-Chloroethyl ethyl carbonate

4-(N-tert-butyloxycarbonylaminomethyl)-cyclohexane-1-carboxylic acid

Refernces

• 1、 -. "Antifibrinolytically active derivatives of tranexamic acid". . . Retrieved 2008/06/13.