(S)-1-[(2R,3R)-3-(4-Benzyloxy-phenyl)-2-tert-butoxycarbonylamino-3-methoxy-propionyl]-piperidine-2-carboxylic acid benzyl ester

Base Information

Chemical Name:(S)-1-[(2R,3R)-3-(4-Benzyloxy-phenyl)-2-tert-butoxycarbonylamino-3-methoxy-propionyl]-piperidine-2-carboxylic acid benzyl ester
CAS No.:868151-78-4
Molecular Formula:C₃₅H₄₂N₂O₇
Molecular Weight:602.728
Hs Code.:

Synonyms:(S)-1-[(2R,3R)-3-(4-Benzyloxy-phenyl)-2-tert-butoxycarbonylamino-3-methoxy-propionyl]-piperidine-2-carboxylic acid benzyl ester

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Chemical Property of (S)-1-[(2R,3R)-3-(4-Benzyloxy-phenyl)-2-tert-butoxycarbonylamino-3-methoxy-propionyl]-piperidine-2-carboxylic acid benzyl ester

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Technology Process of (S)-1-[(2R,3R)-3-(4-Benzyloxy-phenyl)-2-tert-butoxycarbonylamino-3-methoxy-propionyl]-piperidine-2-carboxylic acid benzyl ester

There total 1 articles about (S)-1-[(2R,3R)-3-(4-Benzyloxy-phenyl)-2-tert-butoxycarbonylamino-3-methoxy-propionyl]-piperidine-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 98265-80-6
(S)-2-benzyl 1-tert-butyl piperidine-1,2-dicarboxylate

: 488835-81-0
methyl (2R,3R)-3-(4-benzyloxyphenyl)-2-tert-butoxycarbonylamino-3-methoxypropionic acid

: 868151-78-4
(S)-1-[(2R,3R)-3-(4-Benzyloxy-phenyl)-2-tert-butoxycarbonylamino-3-methoxy-propionyl]-piperidine-2-carboxylic acid benzyl ester

Guidance literature:: (S)-2-benzyl 1-tert-butyl piperidine-1,2-dicarboxylate; With hydrogenchloride; In 1,4-dioxane; water;

methyl (2R,3R)-3-(4-benzyloxyphenyl)-2-tert-butoxycarbonylamino-3-methoxypropionic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2005.08.023

Reference yield: 54.0%

: 868151-78-4
(S)-1-[(2R,3R)-3-(4-Benzyloxy-phenyl)-2-tert-butoxycarbonylamino-3-methoxy-propionyl]-piperidine-2-carboxylic acid benzyl ester

: 868151-77-3
Cbz-N-MeThr(TBS)-OH

: 868151-82-0
(S)-1-[(2R,3R)-2-[(2S,3R)-2-(Benzyloxycarbonyl-methyl-amino)-3-(tert-butyl-dimethyl-silanyloxy)-butyrylamino]-3-(4-benzyloxy-phenyl)-3-methoxy-propionyl]-piperidine-2-carboxylic acid benzyl ester

Guidance literature:: (S)-1-[(2R,3R)-3-(4-Benzyloxy-phenyl)-2-tert-butoxycarbonylamino-3-methoxy-propionyl]-piperidine-2-carboxylic acid benzyl ester; With trifluoroacetic acid;

Cbz-N-MeThr(TBS)-OH; With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
DOI:10.1016/j.tetlet.2005.08.023

Reference yield:

: 868151-78-4
(S)-1-[(2R,3R)-3-(4-Benzyloxy-phenyl)-2-tert-butoxycarbonylamino-3-methoxy-propionyl]-piperidine-2-carboxylic acid benzyl ester

: (S)-1-[(2R,3R)-2-((2S,3R)-3-Hydroxy-2-methylamino-butyrylamino)-3-(4-hydroxy-phenyl)-3-methoxy-propionyl]-piperidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: TFA

1.2: 54 percent / EDCI; HOBt; N-methylmorpholine

2.1: 83 percent / HF / acetonitrile

3.1: 96 percent / H₂ / Pd/C / methanol

With hydrogen fluoride; hydrogen; trifluoroacetic acid; palladium on activated charcoal; In methanol; acetonitrile;
DOI:10.1016/j.tetlet.2005.08.023