3-hydroxy-2-(N-[bis(4-methoxyphenyl)methyl]amino)-2-methylpropanoic acid tert-butyl ester

Base Information

Chemical Name:3-hydroxy-2-(N-[bis(4-methoxyphenyl)methyl]amino)-2-methylpropanoic acid tert-butyl ester
CAS No.:438574-27-7
Molecular Formula:C₂₃H₃₁NO₅
Molecular Weight:401.503
Hs Code.:

Synonyms:3-hydroxy-2-(N-[bis(4-methoxyphenyl)methyl]amino)-2-methylpropanoic acid tert-butyl ester

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Chemical Property of 3-hydroxy-2-(N-[bis(4-methoxyphenyl)methyl]amino)-2-methylpropanoic acid tert-butyl ester

Chemical Property:

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Technology Process of 3-hydroxy-2-(N-[bis(4-methoxyphenyl)methyl]amino)-2-methylpropanoic acid tert-butyl ester

There total 4 articles about 3-hydroxy-2-(N-[bis(4-methoxyphenyl)methyl]amino)-2-methylpropanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7525-23-7
4,4'-dimethoxydiphenylmethyl chloride

: 2-amino-3-hydroxy-2-methyl-propionic acid tert-butyl ester

: 438574-27-7
3-hydroxy-2-(N-[bis(4-methoxyphenyl)methyl]amino)-2-methylpropanoic acid tert-butyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jm010241x

Reference yield:

: 438574-22-2
3-benzyloxy-2-[N-(tert-butoxycarbonyl)amino]-2-methylpropanoic acid tert-butyl ester

: 438574-27-7
3-hydroxy-2-(N-[bis(4-methoxyphenyl)methyl]amino)-2-methylpropanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / H₂ / 10percent Pd/C / methanol

2: p-TsOH*H₂O / diethyl ether; ethanol

3: Et₃N / CH₂Cl₂ / 1 h / 20 °C

With hydrogen; toluene-4-sulfonic acid; triethylamine; 10percent Pd/C; In methanol; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jm010241x

Reference yield:

: 438574-23-3
2-[N-(tert-butoxycarbonyl)amino]-3-hydroxy-2-methylpropanoic acid tert-butyl ester

: 438574-27-7
3-hydroxy-2-(N-[bis(4-methoxyphenyl)methyl]amino)-2-methylpropanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: p-TsOH*H₂O / diethyl ether; ethanol

2: Et₃N / CH₂Cl₂ / 1 h / 20 °C

With toluene-4-sulfonic acid; triethylamine; In diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jm010241x