2,5-dioxo-3-(3-trifluoromethylphenyl)-pyrrolidine-1-carboxylic acid methyl ester

Base Information

Chemical Name:2,5-dioxo-3-(3-trifluoromethylphenyl)-pyrrolidine-1-carboxylic acid methyl ester
CAS No.:1600513-79-8
Molecular Formula:C₁₃H₁₀F₃NO₄
Molecular Weight:301.222
Hs Code.:

Synonyms:2,5-dioxo-3-(3-trifluoromethylphenyl)-pyrrolidine-1-carboxylic acid methyl ester

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Chemical Property of 2,5-dioxo-3-(3-trifluoromethylphenyl)-pyrrolidine-1-carboxylic acid methyl ester

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Technology Process of 2,5-dioxo-3-(3-trifluoromethylphenyl)-pyrrolidine-1-carboxylic acid methyl ester

There total 1 articles about 2,5-dioxo-3-(3-trifluoromethylphenyl)-pyrrolidine-1-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 60050-38-6
3-(3-trifluoromethyl-phenyl)-pyrrolidine-2,5-dione

: 79-22-1
methyl chloroformate

: 1600513-79-8
2,5-dioxo-3-(3-trifluoromethylphenyl)-pyrrolidine-1-carboxylic acid methyl ester

Guidance literature:: With triethylamine; In acetone; at 20 ℃; for 0.5h; Reflux;
DOI:10.1016/j.tetlet.2014.03.021

Reference yield:

: 1600513-79-8
2,5-dioxo-3-(3-trifluoromethylphenyl)-pyrrolidine-1-carboxylic acid methyl ester

: 676-58-4
methylmagnesium chloride

: C₁₅H₁₄F₃NO₂

Guidance literature:: methylmagnesium chloride; With bis(cyclopentadienyl)titanium dichloride; In tetrahydrofuran; diethyl ether; at -10 - 0 ℃; for 1h; Schlenk technique; Inert atmosphere;

2,5-dioxo-3-(3-trifluoromethylphenyl)-pyrrolidine-1-carboxylic acid methyl ester; In tetrahydrofuran; at 65 ℃; for 22h; Schlenk technique; Inert atmosphere;
DOI:10.1016/j.tetlet.2014.03.021

Reference yield:

: 1271-66-5
dimethyltitanocene

: 1600513-79-8
2,5-dioxo-3-(3-trifluoromethylphenyl)-pyrrolidine-1-carboxylic acid methyl ester

: C₁₄H₁₂F₃NO₃

: C₁₄H₁₂F₃NO₃

Guidance literature:: dimethyltitanocene; 2,5-dioxo-3-(3-trifluoromethylphenyl)-pyrrolidine-1-carboxylic acid methyl ester; In tetrahydrofuran; at 65 ℃;

With toluene-4-sulfonic acid; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.tetlet.2014.03.021