ethyl 3-(1-(4-(1H-imidazol-1-yl)phenyl)-2-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-3-yl)propanoate

Base Information

Chemical Name:ethyl 3-(1-(4-(1H-imidazol-1-yl)phenyl)-2-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-3-yl)propanoate
CAS No.:1208330-87-3
Molecular Formula:C₂₆H₂₆N₄O₃
Molecular Weight:442.517
Hs Code.:

Synonyms:ethyl 3-(1-(4-(1H-imidazol-1-yl)phenyl)-2-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-3-yl)propanoate

Suppliers and Price of ethyl 3-(1-(4-(1H-imidazol-1-yl)phenyl)-2-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-3-yl)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 3-(1-(4-(1H-imidazol-1-yl)phenyl)-2-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-3-yl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 3-(1-(4-(1H-imidazol-1-yl)phenyl)-2-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-3-yl)propanoate

There total 14 articles about ethyl 3-(1-(4-(1H-imidazol-1-yl)phenyl)-2-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99548-55-7
4-bromo-2-methyl-benzoic acid methyl ester

: 1208330-87-3
ethyl 3-(1-(4-(1H-imidazol-1-yl)phenyl)-2-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-3-yl)propanoate

Guidance literature:: Multi-step reaction with 13 steps

1.1: N,N-dimethyl-formamide / 8 h / Reflux

2.1: water; sodium hydroxide / ethanol / 12 h / 20 °C

3.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 14 h / 70 °C

4.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C / Inert atmosphere

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

5.2: Inert atmosphere; Reflux

6.1: ozone / dichloromethane / 1 h / -78 °C

7.1: pyridinium p-toluenesulfonate / ethanol / 6 h / 50 °C

8.1: water; dihydrogen peroxide; sodium hydroxide / dimethyl sulfoxide / 4 h / 20 °C

9.1: diisobutylaluminium hydride / toluene / 2 h / -78 °C

10.1: manganese(IV) oxide / dichloromethane / 48 h / Reflux

11.1: toluene / Reflux

12.1: sodium tetrahydroborate; bismuth(III) chloride / ethanol / 20 °C / Cooling with ice

13.1: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 24 h / 130 °C / Molecular sieve

With manganese(IV) oxide; bismuth(III) chloride; sodium tetrahydroborate; copper(l) iodide; n-butyllithium; thionyl chloride; water; dihydrogen peroxide; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; potassium carbonate; ozone; diisopropylamine; N,N-dimethyl-formamide; L-proline; sodium hydroxide; In tetrahydrofuran; ethanol; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil; 11.1: Wittig reaction;
DOI:10.1016/j.bmcl.2011.04.086

Reference yield:

: 288-32-4
1H-imidazole

: 1208331-82-1
ethyl 3-(1-(4-bromophenyl)-2-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-3-yl)propanoate

: 1208330-87-3
ethyl 3-(1-(4-(1H-imidazol-1-yl)phenyl)-2-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-3-yl)propanoate

Guidance literature:: With copper(l) iodide; potassium carbonate; L-proline; In dimethyl sulfoxide; at 130 ℃; for 24h; Molecular sieve;
DOI:10.1016/j.bmcl.2011.04.086

Reference yield:

: 1208331-92-3
(E)-ethyl 3-(1-(4-bromophenyl)-2-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-3-yl)acrylate

: 1208330-87-3
ethyl 3-(1-(4-(1H-imidazol-1-yl)phenyl)-2-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-3-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate; bismuth(III) chloride / ethanol / 20 °C / Cooling with ice

2: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 24 h / 130 °C / Molecular sieve

With bismuth(III) chloride; sodium tetrahydroborate; copper(l) iodide; potassium carbonate; L-proline; In ethanol; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2011.04.086