(R)-1-(1-(4-bromophenyl)-3-hydroxy-2-methylpropan-2-yl)-3-(3,5-dichlorophenyl)-1-methylurea

Base Information

Chemical Name:(R)-1-(1-(4-bromophenyl)-3-hydroxy-2-methylpropan-2-yl)-3-(3,5-dichlorophenyl)-1-methylurea
CAS No.:1393737-31-9
Molecular Formula:C₁₈H₁₉BrCl₂N₂O₂
Molecular Weight:446.171
Hs Code.:

Synonyms:(R)-1-(1-(4-bromophenyl)-3-hydroxy-2-methylpropan-2-yl)-3-(3,5-dichlorophenyl)-1-methylurea

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Chemical Property of (R)-1-(1-(4-bromophenyl)-3-hydroxy-2-methylpropan-2-yl)-3-(3,5-dichlorophenyl)-1-methylurea

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Technology Process of (R)-1-(1-(4-bromophenyl)-3-hydroxy-2-methylpropan-2-yl)-3-(3,5-dichlorophenyl)-1-methylurea

There total 7 articles about (R)-1-(1-(4-bromophenyl)-3-hydroxy-2-methylpropan-2-yl)-3-(3,5-dichlorophenyl)-1-methylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1393737-30-8
(R)-3-(4-bromophenyl)-2-methyl-2-methylamino-1-propanol

: 34893-92-0
3,4-dichlorophenyl isocyanate

: 1393737-31-9
(R)-1-(1-(4-bromophenyl)-3-hydroxy-2-methylpropan-2-yl)-3-(3,5-dichlorophenyl)-1-methylurea

Guidance literature:: (R)-3-(4-bromophenyl)-2-methyl-2-methylamino-1-propanol; With sodium hydride; In tetrahydrofuran; mineral oil;

3,4-dichlorophenyl isocyanate; In tetrahydrofuran; mineral oil; at 20 ℃; for 4h;

With water; sodium chloride; In tetrahydrofuran; mineral oil; Saturated solution;
DOI:10.1016/j.tet.2012.06.090

Reference yield:

: 1393737-27-3
diethyl (R)-2-(4-bromobenzyl)-2-((α-methylbenzyl)amino)malonate hydrochloride

: 1393737-31-9
(R)-1-(1-(4-bromophenyl)-3-hydroxy-2-methylpropan-2-yl)-3-(3,5-dichlorophenyl)-1-methylurea

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydrogencarbonate / water

2.1: lithium aluminium tetrahydride / diethyl ether / 2.5 h / Cooling with ice

2.2: 2 h / 20 °C

3.1: pyridine / dichloromethane / 15 h / 20 °C

3.2: 6 h / 2 °C

4.1: trifluorormethanesulfonic acid; methoxybenzene / nitromethane / 6 h / 50 °C

5.1: pyridine / 6 h / 0 - 20 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Cooling with ice; Reflux

6.2: 19 h / 20 °C

7.1: sodium hydride / tetrahydrofuran; mineral oil

7.2: 4 h / 20 °C

7.3: Saturated solution

With pyridine; lithium aluminium tetrahydride; trifluorormethanesulfonic acid; sodium hydride; sodium hydrogencarbonate; methoxybenzene; In tetrahydrofuran; diethyl ether; nitromethane; dichloromethane; water; mineral oil;
DOI:10.1016/j.tet.2012.06.090

Reference yield:

: 1393737-39-7
(R)-2-(4-bromobenzyl)-2-((α-methylbenzyl)amino)-1,3-propanediol

: 1393737-31-9
(R)-1-(1-(4-bromophenyl)-3-hydroxy-2-methylpropan-2-yl)-3-(3,5-dichlorophenyl)-1-methylurea

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / dichloromethane / 15 h / 20 °C

1.2: 6 h / 2 °C

2.1: trifluorormethanesulfonic acid; methoxybenzene / nitromethane / 6 h / 50 °C

3.1: pyridine / 6 h / 0 - 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Cooling with ice; Reflux

4.2: 19 h / 20 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil

5.2: 4 h / 20 °C

5.3: Saturated solution

With pyridine; lithium aluminium tetrahydride; trifluorormethanesulfonic acid; sodium hydride; methoxybenzene; In tetrahydrofuran; nitromethane; dichloromethane; mineral oil;
DOI:10.1016/j.tet.2012.06.090