[5-(7-fluoro-1-propyl-1H-benzoimidazol-2-yl)-pyridin-2-yl]-(4-methoxy-phenyl)-amine

Base Information

Chemical Name:[5-(7-fluoro-1-propyl-1H-benzoimidazol-2-yl)-pyridin-2-yl]-(4-methoxy-phenyl)-amine
CAS No.:1072930-78-9
Molecular Formula:C₂₂H₂₁FN₄O
Molecular Weight:376.433
Hs Code.:

Synonyms:[5-(7-fluoro-1-propyl-1H-benzoimidazol-2-yl)-pyridin-2-yl]-(4-methoxy-phenyl)-amine

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Chemical Property of [5-(7-fluoro-1-propyl-1H-benzoimidazol-2-yl)-pyridin-2-yl]-(4-methoxy-phenyl)-amine

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Technology Process of [5-(7-fluoro-1-propyl-1H-benzoimidazol-2-yl)-pyridin-2-yl]-(4-methoxy-phenyl)-amine

There total 5 articles about [5-(7-fluoro-1-propyl-1H-benzoimidazol-2-yl)-pyridin-2-yl]-(4-methoxy-phenyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 1072930-79-0
2-(6-chloro-pyridin-3-yl)-7-fluoro-1-propyl-1H-benzoimidazole

: 104-94-9
4-methoxy-aniline

: 1072930-78-9
[5-(7-fluoro-1-propyl-1H-benzoimidazol-2-yl)-pyridin-2-yl]-(4-methoxy-phenyl)-amine

Guidance literature:: With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; In toluene; for 18h; Heating / reflux;

Reference yield:

: 122455-35-0
2-fluoro-6-nitrophenyl trifluoromethanesulfonate

: 1072930-78-9
[5-(7-fluoro-1-propyl-1H-benzoimidazol-2-yl)-pyridin-2-yl]-(4-methoxy-phenyl)-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 1-methyl-pyrrolidin-2-one / 18 h / 130 °C

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 96 h / 20 °C

3: tetrahydrofuran / 19 h / 20 °C / Heating / reflux

4: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 18 h / Heating / reflux

With hydrogen; caesium carbonate; palladium diacetate; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; toluene;

Reference yield:

: 1072928-96-1
3-fluoro-N-2-propyl-benzene-1,2-diamine

: 1072930-78-9
[5-(7-fluoro-1-propyl-1H-benzoimidazol-2-yl)-pyridin-2-yl]-(4-methoxy-phenyl)-amine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 19 h / 20 °C / Heating / reflux

2: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 18 h / Heating / reflux

With caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; toluene;