2,5-difluoro-N-{2-fluoro-3-[(pyridin-4-yl)acetyl]phenyl}-N-(methoxymethyl)benzenesulfonamide

Base Information

Chemical Name:2,5-difluoro-N-{2-fluoro-3-[(pyridin-4-yl)acetyl]phenyl}-N-(methoxymethyl)benzenesulfonamide
CAS No.:1394939-44-6
Molecular Formula:C₂₁H₁₇F₃N₂O₄S
Molecular Weight:450.438
Hs Code.:

Synonyms:2,5-difluoro-N-{2-fluoro-3-[(pyridin-4-yl)acetyl]phenyl}-N-(methoxymethyl)benzenesulfonamide

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Chemical Property of 2,5-difluoro-N-{2-fluoro-3-[(pyridin-4-yl)acetyl]phenyl}-N-(methoxymethyl)benzenesulfonamide

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Technology Process of 2,5-difluoro-N-{2-fluoro-3-[(pyridin-4-yl)acetyl]phenyl}-N-(methoxymethyl)benzenesulfonamide

There total 7 articles about 2,5-difluoro-N-{2-fluoro-3-[(pyridin-4-yl)acetyl]phenyl}-N-(methoxymethyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 108-89-4
picoline

: 1394938-68-1
3-{[(2,5-difluorophenyl)sulfonyl](methoxymethyl)amino}-2-fluoro-N-methoxy-N-methylbenzamide

: 1394939-44-6
2,5-difluoro-N-{2-fluoro-3-[(pyridin-4-yl)acetyl]phenyl}-N-(methoxymethyl)benzenesulfonamide

Guidance literature:: picoline; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

3-{[(2,5-difluorophenyl)sulfonyl](methoxymethyl)amino}-2-fluoro-N-methoxy-N-methylbenzamide; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 1h; Inert atmosphere;
DOI:10.1002/cmdc.201402424

Reference yield:

: 58534-95-5
3-bromo-2-fluorobenzenamine

: 1394939-44-6
2,5-difluoro-N-{2-fluoro-3-[(pyridin-4-yl)acetyl]phenyl}-N-(methoxymethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

3.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / 0 - 20 °C

3.2: 0.33 h / 0 °C

4.1: 4-methyl-morpholine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; 1,2-dimethoxyethane / 4 h / 0 - 20 °C

5.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

5.2: 1 h / -78 - 0 °C / Inert atmosphere

With 4-methyl-morpholine; pyridine; dmap; isopropylmagnesium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; 3.1: |Grignard Reaction / 3.2: |Grignard Reaction;
DOI:10.1002/cmdc.201402424

Reference yield:

: 1394938-70-5
3-{[(2,5-difluorophenyl)sulfonyl](methoxymethyl)amino}-2-fluorobenzoic acid

: 1394939-44-6
2,5-difluoro-N-{2-fluoro-3-[(pyridin-4-yl)acetyl]phenyl}-N-(methoxymethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 4-methyl-morpholine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; 1,2-dimethoxyethane / 4 h / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 - 0 °C / Inert atmosphere

With 4-methyl-morpholine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1002/cmdc.201402424