2-debenzoyl-2-(3-chlorobenzoyl)-7-triethylsilylbaccatin III

Base Information

• Chemical Name: 2-debenzoyl-2-(3-chlorobenzoyl)-7-triethylsilylbaccatin III
• CAS No.: 189190-87-2
• Molecular Formula: C₃₇H₅₁ClO₁₁Si
• Molecular Weight: 735.344
• Mol file: 189190-87-2.mol

Synonyms:2-debenzoyl-2-(3-chlorobenzoyl)-7-triethylsilylbaccatin III

Chemical Property of 2-debenzoyl-2-(3-chlorobenzoyl)-7-triethylsilylbaccatin III

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-debenzoyl-2-(3-chlorobenzoyl)-7-triethylsilylbaccatin III

There total 13 articles about 2-debenzoyl-2-(3-chlorobenzoyl)-7-triethylsilylbaccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

triethylsilyl chloride (994-30-9) + C31H37ClO11 (1134620-16-8) → 2-debenzoyl-2-(3-chlorobenzoyl)-7-triethylsilylbaccatin III (189190-87-2)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.jfluchem.2008.05.013

Reference yield:

triethylsilyl chloride (994-30-9) → 2-debenzoyl-2-(3-chlorobenzoyl)-7-triethylsilylbaccatin III (189190-87-2)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole / 20 °C

2: LiHMDS

With 1H-imidazole; lithium hexamethyldisilazane;

DOI:10.1016/j.bmcl.2004.05.027

Reference yield:

10-O-deacetyl-2-O-debenzoyl-7,10,13-O-tris(triethylsilyl)baccatin III (204580-30-3) → 2-debenzoyl-2-(3-chlorobenzoyl)-7-triethylsilylbaccatin III (189190-87-2)

Guidance literature:

Multi-step reaction with 4 steps

1: DIC; DMAP

2: HF*pyridine / 40 h / 20 °C

3: imidazole / 20 °C

4: LiHMDS

With 1H-imidazole; dmap; pyridine hydrogenfluoride; dacarbazine; lithium hexamethyldisilazane;

DOI:10.1016/j.bmcl.2004.05.027

upstream raw materials:

2-(m-chlorobenzoyl)-2-debenzoyl-7-(triethylsilyl)-13-oxobaccatin III

acetyl chloride

triethylsilyl chloride

10-O-deacetyl-2-O-debenzoyl-7,10,13-O-tris(triethylsilyl)baccatin III

Downstream raw materials:

C₃₇H₄₈Cl₂O₉Si

3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-acetyl-docetaxel

C₅₄H₇₁ClN₂O₁₃Si

C₃₇H₄₈ClN₃O₉Si