Technology Process of 8-Indolizinol, octahydro-1,2,7-tris(phenylmethoxy)-, 1S-(1.alpha.,2.beta.,7.alpha.,8.alpha.,8a.alpha.)-
There total 1 articles about 8-Indolizinol, octahydro-1,2,7-tris(phenylmethoxy)-, 1S-(1.alpha.,2.beta.,7.alpha.,8.alpha.,8a.alpha.)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
1-thiopropane; tetrabutylammomium bromide; lithium hydride; di(n-butyl)tin oxide;
Yield given. Multistep reaction. Yields of byproduct given;
1.) MePh, reflux, 2 h, 2.) MePh, reflux, 3 days, 3.) DMSO, 3 h;
DOI:10.1016/0040-4020(95)00803-G
- Guidance literature:
-
Multi-step reaction with 6 steps
1: Et3N / CH2Cl2
2: dimethylsulfoxide / 1 h / 90 °C
3: NaH2PO2, Raney Ni / pyridine; acetic acid / Ambient temperature
4: TsOH / CH2Cl2; acetone / 0.33 h
5: NaBH4 / methanol
6: 30 percent / DAST / CH2Cl2 / 4 h / Ambient temperature
With
sodium tetrahydroborate; sodium hypophosphite; nickel; toluene-4-sulfonic acid; triethylamine; 4,4'-diaminostilbene-2,2'-disulfonic acid;
In
pyridine; methanol; dichloromethane; acetic acid; dimethyl sulfoxide; acetone;
DOI:10.1016/0040-4020(95)00803-G
- Guidance literature:
-
Multi-step reaction with 3 steps
1: Et3N / CH2Cl2
2: dimethylsulfoxide / 1 h / 90 °C
3: NaH2PO2, Raney Ni / pyridine; acetic acid / Ambient temperature
With
sodium hypophosphite; nickel; triethylamine;
In
pyridine; dichloromethane; acetic acid; dimethyl sulfoxide;
DOI:10.1016/0040-4020(95)00803-G