(S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-N-(2-cyclohexyl-2-hydroxyethyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxamide

Base Information

• Chemical Name: (S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-N-(2-cyclohexyl-2-hydroxyethyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxamide
• CAS No.: 1224735-53-8
• Molecular Formula: C₂₇H₄₃N₃O₄Si
• Molecular Weight: 501.742

Synonyms:(S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-N-(2-cyclohexyl-2-hydroxyethyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxamide

Chemical Property of (S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-N-(2-cyclohexyl-2-hydroxyethyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxamide

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Technology Process of (S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-N-(2-cyclohexyl-2-hydroxyethyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxamide

There total 1 articles about (S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-N-(2-cyclohexyl-2-hydroxyethyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid (1224680-14-1) + 1-amino-2-cyclohexylethan-2-ol (57230-08-7) → (S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-N-(2-cyclohexyl-2-hydroxyethyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxamide (1224735-53-8)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N,N-dimethyl-formamide; at 25 ℃;

Reference yield: 23.0%

(S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-N-(2-cyclohexyl-2-hydroxyethyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxamide (1224735-53-8) → (S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-5((R)-5-cyclohexyl-4,5-dihydrooxazol-2-yl)-6-ethyl-3,4-dihydropyrimidin-2(1H)-one (1224735-54-9) + (S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-5((S)-5-cyclohexyl-4,5-dihydrooxazol-2-yl)-6-ethyl-3,4-dihydropyrimidin-2(1H)-one (1224735-55-0)

Guidance literature:

With Burgess Reagent; In tetrahydrofuran; at 70 ℃; for 1h;

upstream raw materials:

(S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid

1-amino-2-cyclohexylethan-2-ol

Downstream raw materials:

(S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-5((R)-5-cyclohexyl-4,5-dihydrooxazol-2-yl)-6-ethyl-3,4-dihydropyrimidin-2(1H)-one

(S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-5((S)-5-cyclohexyl-4,5-dihydrooxazol-2-yl)-6-ethyl-3,4-dihydropyrimidin-2(1H)-one

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