(S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid

Base Information

Chemical Name:(S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid
CAS No.:1224680-14-1
Molecular Formula:C₁₉H₂₈N₂O₄Si
Molecular Weight:376.528
Hs Code.:

Synonyms:(S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid

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Chemical Property of (S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid

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Technology Process of (S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid

There total 5 articles about (S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1224680-15-2
C₁₉H₂₂N₂O*C₁₉H₂₈N₂O₄Si

: 1224680-14-1
(S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid

Guidance literature:: With hydrogenchloride; In water; pH=2;
DOI:10.1016/j.bmcl.2011.12.090

Reference yield:

: 1224680-13-0
C₁₉H₂₈N₂O₄Si

: 1224680-14-1
(S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / -20 - 76 °C

2: hydrogenchloride / water / pH 2

With hydrogenchloride; In methanol; water;
DOI:10.1016/j.bmcl.2011.12.090

Reference yield:

: 4949-45-5
benzyl 2-methylacetoacetate

: 1224680-14-1
(S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: ytterbium(III) triflate / tetrahydrofuran / 24 h / Reflux

2.1: 1H-imidazole / N,N-dimethyl-formamide / 25 °C

3.1: palladium 10% on activated carbon; hydrogen; triethylamine / methanol / 3 h / 25 °C / 2250.23 Torr

3.2: pH 2

4.1: methanol / -20 - 76 °C

5.1: hydrogenchloride / water / pH 2

With 1H-imidazole; hydrogenchloride; palladium 10% on activated carbon; hydrogen; triethylamine; ytterbium(III) triflate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; 1.1: Biginelli pyrimidine synthesis;
DOI:10.1016/j.bmcl.2011.12.090