5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyrimidine-2-carbonitrile

Base Information

Chemical Name:5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyrimidine-2-carbonitrile
CAS No.:1272354-91-2
Molecular Formula:C₂₅H₁₇N₇
Molecular Weight:415.457
Hs Code.:

Synonyms:5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyrimidine-2-carbonitrile

Suppliers and Price of 5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyrimidine-2-carbonitrile

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Chemical Property of 5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyrimidine-2-carbonitrile

Chemical Property:

Purity/Quality:: 98%min ^*data from raw suppliers

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Technology Process of 5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyrimidine-2-carbonitrile

There total 6 articles about 5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyrimidine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1025708-31-9
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine-2-carbonitrile

: 1272353-93-1
2-chloro-5-phenyl-N-(pyridin-2-ylmethyl)quinazolin-4-amine

: 1272354-91-2
5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyrimidine-2-carbonitrile

Guidance literature:: With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 90 ℃; for 16h; Inert atmosphere;

Reference yield:

: 959237-01-5
5-bromoquinazoline-2,4(1H,3H)-dione

: 1272354-91-2
5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyrimidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 40 h / Reflux

2: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 105 °C

3: triethylamine / tetrahydrofuran / 14 h / 20 °C

4: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 90 °C / Inert atmosphere

With sodium hydrogencarbonate; potassium carbonate; N,N-dimethyl-aniline; triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water;

Reference yield:

: 20780-72-7
4-bromoisatin

: 1272354-91-2
5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyrimidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; dihydrogen peroxide / 1.25 h / 80 °C

1.2: pH 4 - 5

2.1: acetic acid / water / 35 °C

3.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 40 h / Reflux

4.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 105 °C

5.1: triethylamine / tetrahydrofuran / 14 h / 20 °C

6.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 90 °C / Inert atmosphere

With dihydrogen peroxide; sodium hydrogencarbonate; potassium carbonate; acetic acid; N,N-dimethyl-aniline; triethylamine; sodium hydroxide; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water;