5-cyclopropyl-2-(4-fluorophenyl)-N'-hydroxy-6-{(methylsulfonyl)[2-(methylsulfonyl)ethyl]amino}-1-benzofuran-3-carboximidamide

Base Information

Chemical Name:5-cyclopropyl-2-(4-fluorophenyl)-N'-hydroxy-6-{(methylsulfonyl)[2-(methylsulfonyl)ethyl]amino}-1-benzofuran-3-carboximidamide
CAS No.:1383851-85-1
Molecular Formula:C₂₂H₂₄FN₃O₆S₂
Molecular Weight:509.579
Hs Code.:

Synonyms:5-cyclopropyl-2-(4-fluorophenyl)-N'-hydroxy-6-{(methylsulfonyl)[2-(methylsulfonyl)ethyl]amino}-1-benzofuran-3-carboximidamide

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Chemical Property of 5-cyclopropyl-2-(4-fluorophenyl)-N'-hydroxy-6-{(methylsulfonyl)[2-(methylsulfonyl)ethyl]amino}-1-benzofuran-3-carboximidamide

Chemical Property:

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Technology Process of 5-cyclopropyl-2-(4-fluorophenyl)-N'-hydroxy-6-{(methylsulfonyl)[2-(methylsulfonyl)ethyl]amino}-1-benzofuran-3-carboximidamide

There total 18 articles about 5-cyclopropyl-2-(4-fluorophenyl)-N'-hydroxy-6-{(methylsulfonyl)[2-(methylsulfonyl)ethyl]amino}-1-benzofuran-3-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383851-84-0
N-[3-cyano-5-cyclopropyl-2-(4-fluorophenyl)-1-benzofuran-6-yl]-N-[2-(methylsulfinyl)ethyl]methanesulfonamide

: 1383851-83-9
N-[3-cyano-5-cyclopropyl-2-(4-fluorophenyl)-1-benzofuran-6-yl]-N-[2-(methylsulfonyl)ethyl]methanesulfonamide

: 1383851-86-2
5-cyclopropyl-2-(4-fluorophenyl)-N'-hydroxy-6-{[2-(methylsulfinyl)ethyl](methylsulfonyl)amino}-1-benzofuran-3-carboximidamide

: 1383851-85-1
5-cyclopropyl-2-(4-fluorophenyl)-N'-hydroxy-6-{(methylsulfonyl)[2-(methylsulfonyl)ethyl]amino}-1-benzofuran-3-carboximidamide

Guidance literature:: With hydroxylamine; In ethanol; water; at 140 ℃; for 0.5h; sealed tube; microwave;

Reference yield:

: 691857-46-2
ethyl 2-(4-fluorophenyl)-5-hydroxy-6-nitrobenzofuran-3-carboxylate

: 1383851-85-1
5-cyclopropyl-2-(4-fluorophenyl)-N'-hydroxy-6-{(methylsulfonyl)[2-(methylsulfonyl)ethyl]amino}-1-benzofuran-3-carboximidamide

Guidance literature:: Multi-step reaction with 13 steps

1.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h

2.1: potassium fluoride dihydrate; sodium bromide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 18 h / 125 °C / Inert atmosphere; sealed vessel

3.1: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 1.5 h / Inert atmosphere; Reflux

4.1: pyridine / dichloromethane / 3.33 h / 20 °C / Inert atmosphere

5.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 50 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 10 - 20 °C / Inert atmosphere

6.2: 20 °C / Inert atmosphere

7.1: dipyridinium dichromate / dichloromethane / 18 h / 20 °C

8.1: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / 2 h / Reflux

9.1: acetic anhydride / 16 h / 140 °C

10.1: trifluoroacetic acid / dichloromethane / 3 h / Cooling with ice

11.1: potassium carbonate; sodium iodide / ISOPROPYLAMIDE / 20 h / 53 °C / sealed tube

12.1: Oxone / methanol; water / 28.5 h / 0 - 50 °C

13.1: hydroxylamine / ethanol; water / 0.5 h / 140 °C / sealed tube; microwave

With pyridine; dmap; Oxone; lithium aluminium tetrahydride; dipyridinium dichromate; potassium fluoride dihydrate; hydroxylamine hydrochloride; hydroxylamine; acetic anhydride; iron; sodium carbonate; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium iodide; sodium bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 691857-51-9
ethyl 2-(4-fluorophenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate

: 1383851-85-1
5-cyclopropyl-2-(4-fluorophenyl)-N'-hydroxy-6-{(methylsulfonyl)[2-(methylsulfonyl)ethyl]amino}-1-benzofuran-3-carboximidamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: potassium fluoride dihydrate; sodium bromide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 18 h / 125 °C / Inert atmosphere; sealed vessel

2.1: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 1.5 h / Inert atmosphere; Reflux

3.1: pyridine / dichloromethane / 3.33 h / 20 °C / Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 50 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 10 - 20 °C / Inert atmosphere

5.2: 20 °C / Inert atmosphere

6.1: dipyridinium dichromate / dichloromethane / 18 h / 20 °C

7.1: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / 2 h / Reflux

8.1: acetic anhydride / 16 h / 140 °C

9.1: trifluoroacetic acid / dichloromethane / 3 h / Cooling with ice

10.1: potassium carbonate; sodium iodide / ISOPROPYLAMIDE / 20 h / 53 °C / sealed tube

11.1: Oxone / methanol; water / 28.5 h / 0 - 50 °C

12.1: hydroxylamine / ethanol; water / 0.5 h / 140 °C / sealed tube; microwave

With pyridine; Oxone; lithium aluminium tetrahydride; dipyridinium dichromate; potassium fluoride dihydrate; hydroxylamine hydrochloride; hydroxylamine; acetic anhydride; iron; sodium carbonate; potassium carbonate; ammonium chloride; trifluoroacetic acid; sodium iodide; sodium bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; toluene;