N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(5-methyl-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1-benzofuran-6-yl]-N-[2-(methylsulfonyl)ethyl]methanesulfonamide

Base Information

Chemical Name:N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(5-methyl-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1-benzofuran-6-yl]-N-[2-(methylsulfonyl)ethyl]methanesulfonamide
CAS No.:1383851-81-7
Molecular Formula:C₂₄H₂₆FN₃O₆S₂
Molecular Weight:535.617
Hs Code.:

Synonyms:N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(5-methyl-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1-benzofuran-6-yl]-N-[2-(methylsulfonyl)ethyl]methanesulfonamide

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Chemical Property of N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(5-methyl-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1-benzofuran-6-yl]-N-[2-(methylsulfonyl)ethyl]methanesulfonamide

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Technology Process of N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(5-methyl-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1-benzofuran-6-yl]-N-[2-(methylsulfonyl)ethyl]methanesulfonamide

There total 19 articles about N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(5-methyl-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1-benzofuran-6-yl]-N-[2-(methylsulfonyl)ethyl]methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383851-86-2
5-cyclopropyl-2-(4-fluorophenyl)-N'-hydroxy-6-{[2-(methylsulfinyl)ethyl](methylsulfonyl)amino}-1-benzofuran-3-carboximidamide

: 1383851-85-1
5-cyclopropyl-2-(4-fluorophenyl)-N'-hydroxy-6-{(methylsulfonyl)[2-(methylsulfonyl)ethyl]amino}-1-benzofuran-3-carboximidamide

: 75-07-0,9002-91-9
acetaldehyde

: 1383851-87-3
N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(5-methyl-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1-benzofuran-6-yl]-N-[2-(methylsulfinyl)ethyl]methanesulfonamide

: 1383851-81-7
N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(5-methyl-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1-benzofuran-6-yl]-N-[2-(methylsulfonyl)ethyl]methanesulfonamide

Guidance literature:: In ethanol; water; at 20 ℃; for 144h;

Reference yield:

: 691857-07-5
ethyl 2-(4-fluorophenyl)-5-isopropoxy-6-nitrobenzofuran-3-carboxylate

: 1383851-81-7
N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(5-methyl-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1-benzofuran-6-yl]-N-[2-(methylsulfonyl)ethyl]methanesulfonamide

Guidance literature:: Multi-step reaction with 15 steps

1.1: boron trichloride / dichloromethane / 1 h / 0 - 20 °C

1.2: 20 °C

2.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h

3.1: potassium fluoride dihydrate; sodium bromide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 18 h / 125 °C / Inert atmosphere; sealed vessel

4.1: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 1.5 h / Inert atmosphere; Reflux

5.1: pyridine / dichloromethane / 3.33 h / 20 °C / Inert atmosphere

6.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 50 °C

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 10 - 20 °C / Inert atmosphere

7.2: 20 °C / Inert atmosphere

8.1: dipyridinium dichromate / dichloromethane / 18 h / 20 °C

9.1: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / 2 h / Reflux

10.1: acetic anhydride / 16 h / 140 °C

11.1: trifluoroacetic acid / dichloromethane / 3 h / Cooling with ice

12.1: potassium carbonate; sodium iodide / ISOPROPYLAMIDE / 20 h / 53 °C / sealed tube

13.1: Oxone / methanol; water / 28.5 h / 0 - 50 °C

14.1: hydroxylamine / ethanol; water / 0.5 h / 140 °C / sealed tube; microwave

15.1: ethanol; water / 144 h / 20 °C

With pyridine; dmap; Oxone; lithium aluminium tetrahydride; dipyridinium dichromate; potassium fluoride dihydrate; hydroxylamine hydrochloride; hydroxylamine; acetic anhydride; boron trichloride; iron; sodium carbonate; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium iodide; sodium bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 691857-46-2
ethyl 2-(4-fluorophenyl)-5-hydroxy-6-nitrobenzofuran-3-carboxylate

: 1383851-81-7
N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(5-methyl-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1-benzofuran-6-yl]-N-[2-(methylsulfonyl)ethyl]methanesulfonamide

Guidance literature:: Multi-step reaction with 14 steps

1.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h

2.1: potassium fluoride dihydrate; sodium bromide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 18 h / 125 °C / Inert atmosphere; sealed vessel

3.1: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 1.5 h / Inert atmosphere; Reflux

4.1: pyridine / dichloromethane / 3.33 h / 20 °C / Inert atmosphere

5.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 50 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 10 - 20 °C / Inert atmosphere

6.2: 20 °C / Inert atmosphere

7.1: dipyridinium dichromate / dichloromethane / 18 h / 20 °C

8.1: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / 2 h / Reflux

9.1: acetic anhydride / 16 h / 140 °C

10.1: trifluoroacetic acid / dichloromethane / 3 h / Cooling with ice

11.1: potassium carbonate; sodium iodide / ISOPROPYLAMIDE / 20 h / 53 °C / sealed tube

12.1: Oxone / methanol; water / 28.5 h / 0 - 50 °C

13.1: hydroxylamine / ethanol; water / 0.5 h / 140 °C / sealed tube; microwave

14.1: ethanol; water / 144 h / 20 °C

With pyridine; dmap; Oxone; lithium aluminium tetrahydride; dipyridinium dichromate; potassium fluoride dihydrate; hydroxylamine hydrochloride; hydroxylamine; acetic anhydride; iron; sodium carbonate; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium iodide; sodium bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; toluene;