5-cyclopropyl-2-(4-fluorophenyl)-N'-hydroxy-6-{[2-(methylsulfinyl)ethyl](methylsulfonyl)amino}-1-benzofuran-3-carboximidamide

Base Information

• Chemical Name: 5-cyclopropyl-2-(4-fluorophenyl)-N'-hydroxy-6-{[2-(methylsulfinyl)ethyl](methylsulfonyl)amino}-1-benzofuran-3-carboximidamide
• CAS No.: 1383851-86-2
• Molecular Formula: C₂₂H₂₄FN₃O₅S₂
• Molecular Weight: 493.58

Synonyms:5-cyclopropyl-2-(4-fluorophenyl)-N'-hydroxy-6-{[2-(methylsulfinyl)ethyl](methylsulfonyl)amino}-1-benzofuran-3-carboximidamide

Chemical Property of 5-cyclopropyl-2-(4-fluorophenyl)-N'-hydroxy-6-{[2-(methylsulfinyl)ethyl](methylsulfonyl)amino}-1-benzofuran-3-carboximidamide

Chemical Property:

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Technology Process of 5-cyclopropyl-2-(4-fluorophenyl)-N'-hydroxy-6-{[2-(methylsulfinyl)ethyl](methylsulfonyl)amino}-1-benzofuran-3-carboximidamide

There total 1 articles about 5-cyclopropyl-2-(4-fluorophenyl)-N'-hydroxy-6-{[2-(methylsulfinyl)ethyl](methylsulfonyl)amino}-1-benzofuran-3-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[3-cyano-5-cyclopropyl-2-(4-fluorophenyl)-1-benzofuran-6-yl]-N-[2-(methylsulfinyl)ethyl]methanesulfonamide (1383851-84-0) + N-[3-cyano-5-cyclopropyl-2-(4-fluorophenyl)-1-benzofuran-6-yl]-N-[2-(methylsulfonyl)ethyl]methanesulfonamide (1383851-83-9) → 5-cyclopropyl-2-(4-fluorophenyl)-N'-hydroxy-6-{[2-(methylsulfinyl)ethyl](methylsulfonyl)amino}-1-benzofuran-3-carboximidamide (1383851-86-2) + 5-cyclopropyl-2-(4-fluorophenyl)-N'-hydroxy-6-{(methylsulfonyl)[2-(methylsulfonyl)ethyl]amino}-1-benzofuran-3-carboximidamide (1383851-85-1)

Guidance literature:

With hydroxylamine; In ethanol; water; at 140 ℃; for 0.5h; sealed tube; microwave;

Reference yield:

5-cyclopropyl-2-(4-fluorophenyl)-N'-hydroxy-6-{[2-(methylsulfinyl)ethyl](methylsulfonyl)amino}-1-benzofuran-3-carboximidamide (1383851-86-2) + 5-cyclopropyl-2-(4-fluorophenyl)-N'-hydroxy-6-{(methylsulfonyl)[2-(methylsulfonyl)ethyl]amino}-1-benzofuran-3-carboximidamide (1383851-85-1) + acetaldehyde (75-07-0,9002-91-9) → N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(5-methyl-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1-benzofuran-6-yl]-N-[2-(methylsulfinyl)ethyl]methanesulfonamide (1383851-87-3) + N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(5-methyl-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1-benzofuran-6-yl]-N-[2-(methylsulfonyl)ethyl]methanesulfonamide (1383851-81-7)

Guidance literature:

In ethanol; water; at 20 ℃; for 144h;

upstream raw materials:

N-[3-cyano-5-cyclopropyl-2-(4-fluorophenyl)-1-benzofuran-6-yl]-N-[2-(methylsulfinyl)ethyl]methanesulfonamide

N-[3-cyano-5-cyclopropyl-2-(4-fluorophenyl)-1-benzofuran-6-yl]-N-[2-(methylsulfonyl)ethyl]methanesulfonamide

Downstream raw materials:

N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(5-methyl-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1-benzofuran-6-yl]-N-[2-(methylsulfinyl)ethyl]methanesulfonamide

N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(5-methyl-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1-benzofuran-6-yl]-N-[2-(methylsulfonyl)ethyl]methanesulfonamide

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