Folic Acid-D4

Base Information

• Chemical Name: Folic Acid-D4
• CAS No.: 171777-72-3
• Molecular Formula: C19H15 D4 N7 O6
• Molecular Weight: 445.48
• Mol file: 171777-72-3.mol

Synonyms:Folic Acid-D4;N-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl-2,3,5,6-d4]-L-glutamic Aci;(N-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl-2,3,5,6-d4]-L-);N-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl-2,3,5,6-d4]-L-glutamic Acid

Chemical Property of Folic Acid-D4

Chemical Property:

• Melting Point: >200?C (dec.)
• PSA: 213.54000
• LogP: 1.41260
• Storage Temp.: Refrigerator
• Solubility.: Aqueous Base (Slightly), DMSO (Slightly, Heated, Sonicated)

Purity/Quality:

99% ^*data from raw suppliers

Folic Acid-d4 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate. A labeled vitamers of folic acid used as internal standards in stable isotope dilution assays As a vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, folic acid-D4 also acts as a cofactor in biological reactions involving folate.

Technology Process of Folic Acid-D4

There total 21 articles about Folic Acid-D4 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N2-acetyl[2H4]folic acid (461426-36-8) → <2',3',5',6'-2H4>folic acid (171777-72-3)

Guidance literature:

With sodium hydroxide; at 20 ℃; for 6h;

DOI:10.1021/jf025571k

Reference yield:

(2)H8-toluene (2037-26-5) → <2',3',5',6'-2H4>folic acid (171777-72-3)

Guidance literature:

Multi-step reaction with 7 steps

1: 1.) HNO₃, <2H₂>sulfuric acid, 2.) sodium dichromate, H₂SO₄ / 1.) D₂O, 1.5 h, 2.) H₂O, reflux, 5 h

2: 2.43 g / PCl₅ / 0.25 h / 60 °C

3: 2.39 g / triethylamine / benzene / 0.25 h / Ambient temperature

4: 0.862 g / H₂ / 10percent Pd/C / ethanol / 1 h

5: 262 mg / 0.25 h / 120 - 125 °C / 0.01 Torr

6: 118 mg / sodium borohydride / ethanol / 45 °C

7: 81 mg / NaOH / 80 °C

With sodium hydroxide; sodium tetrahydroborate; sodium dichromate; phosphorus pentachloride; sulfuric acid; hydrogen; nitric acid; sulfuric acid-d2; triethylamine; palladium on activated charcoal; In ethanol; benzene;

DOI:10.1002/jlcr.2580361010

Reference yield:

4-nitro<2,3,5,6-2H4>benzoic acid (171777-66-5) → <2',3',5',6'-2H4>folic acid (171777-72-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 2.43 g / PCl₅ / 0.25 h / 60 °C

2: 2.39 g / triethylamine / benzene / 0.25 h / Ambient temperature

3: 0.862 g / H₂ / 10percent Pd/C / ethanol / 1 h

4: 262 mg / 0.25 h / 120 - 125 °C / 0.01 Torr

5: 118 mg / sodium borohydride / ethanol / 45 °C

6: 81 mg / NaOH / 80 °C

With sodium hydroxide; sodium tetrahydroborate; phosphorus pentachloride; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; benzene;

DOI:10.1002/jlcr.2580361010

upstream raw materials:

N(2')-acetyl-6-benzoyl)-L-glutamic acid diethyl ester>-pterin

N²-acetyl[2H₄]folic acid

2,4-diamino-6-formylpteridine dimethyl acetal

L-glutamic acid dimethyl ester

Refernces

• 1、 Dueker,Jones,Smith,Clifford. "Preparation of [2',3',5',6'-2H4]pteroylglutamic acid". . p. 981 - 991. Retrieved 2007/10/02.