(-)-(2S,3S,6E)-2,3-epoxy-2,6-dimethyl-8-(4-methylbenzenesulfonyl)-6-octen-1-yl 4-methylbenzenesulfonate

Base Information

Chemical Name:(-)-(2S,3S,6E)-2,3-epoxy-2,6-dimethyl-8-(4-methylbenzenesulfonyl)-6-octen-1-yl 4-methylbenzenesulfonate
CAS No.:142720-39-6
Molecular Formula:C₂₄H₃₀O₆S₂
Molecular Weight:478.631
Hs Code.:

Synonyms:(-)-(2S,3S,6E)-2,3-epoxy-2,6-dimethyl-8-(4-methylbenzenesulfonyl)-6-octen-1-yl 4-methylbenzenesulfonate

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Chemical Property of (-)-(2S,3S,6E)-2,3-epoxy-2,6-dimethyl-8-(4-methylbenzenesulfonyl)-6-octen-1-yl 4-methylbenzenesulfonate

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Technology Process of (-)-(2S,3S,6E)-2,3-epoxy-2,6-dimethyl-8-(4-methylbenzenesulfonyl)-6-octen-1-yl 4-methylbenzenesulfonate

There total 4 articles about (-)-(2S,3S,6E)-2,3-epoxy-2,6-dimethyl-8-(4-methylbenzenesulfonyl)-6-octen-1-yl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 142720-38-5
(-)-(2S,3S,6E)-2,3-epoxy-2,6-dimethyl-8-(4-methylbenzenesulfonyl)-6-octen-1-ol

: 98-59-9
p-toluenesulfonyl chloride

: 142720-39-6
(-)-(2S,3S,6E)-2,3-epoxy-2,6-dimethyl-8-(4-methylbenzenesulfonyl)-6-octen-1-yl 4-methylbenzenesulfonate

Guidance literature:: With pyridine; In chloroform; at 0 ℃; for 2.5h;
DOI:10.1021/jo00043a014

Reference yield:

: 53254-60-7
3,7-dimethyl-1-(p-toluenesulfonyl)-2(E),6-octadiene

: 142720-39-6
(-)-(2S,3S,6E)-2,3-epoxy-2,6-dimethyl-8-(4-methylbenzenesulfonyl)-6-octen-1-yl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) tert-BuOOH, 2.) NaBH₄ / 1.) SeO₂, salicylic acid / 1.) CH₂Cl₂, room temperature, 24 h, 2.) abs. ethanol, 0 deg C, 15 min

2: t-BuOOH, powered activated 4-Angstroem molecular sieves / (+)-diisopropyl L-tartrate, titanium(IV) isopropoxide / CH₂Cl₂; 2,2,4-trimethyl-pentane / 3.5 h / -23 °C

3: 98 percent / pyridine / CHCl₃ / 2.5 h / 0 °C

With pyridine; tert.-butylhydroperoxide; sodium tetrahydroborate; 4 A molecular sieve; titanium(IV) isopropylate; selenium(IV) oxide; L-(+)-diisopropyl tartrate; salicylic acid; In 2,2,4-trimethylpentane; dichloromethane; chloroform;
DOI:10.1021/jo00043a014

Reference yield:

: 70238-35-6
(2E,6E)-3,7-dimethyl-1-(4-methylbenzenesulfonyl)-2,6-octadien-8-ol

: 142720-39-6
(-)-(2S,3S,6E)-2,3-epoxy-2,6-dimethyl-8-(4-methylbenzenesulfonyl)-6-octen-1-yl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: t-BuOOH, powered activated 4-Angstroem molecular sieves / (+)-diisopropyl L-tartrate, titanium(IV) isopropoxide / CH₂Cl₂; 2,2,4-trimethyl-pentane / 3.5 h / -23 °C

2: 98 percent / pyridine / CHCl₃ / 2.5 h / 0 °C

With pyridine; tert.-butylhydroperoxide; 4 A molecular sieve; titanium(IV) isopropylate; L-(+)-diisopropyl tartrate; In 2,2,4-trimethylpentane; dichloromethane; chloroform;
DOI:10.1021/jo00043a014