benzyl (3R,4R,5R*)-5-(2'-tert-butyldimethylsilyloxyethyl)-3-p-methoxyphenyl-2-phenylisoxazolidine-4-carboxylate

Base Information

Chemical Name:benzyl (3R*,4R*,5R*)-5-(2'-tert-butyldimethylsilyloxyethyl)-3-p-methoxyphenyl-2-phenylisoxazolidine-4-carboxylate
CAS No.:107699-46-7
Molecular Formula:C₃₂H₄₁NO₅Si
Molecular Weight:547.767
Hs Code.:

Synonyms:benzyl (3R*,4R*,5R*)-5-(2'-tert-butyldimethylsilyloxyethyl)-3-p-methoxyphenyl-2-phenylisoxazolidine-4-carboxylate

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Chemical Property of benzyl (3R*,4R*,5R*)-5-(2'-tert-butyldimethylsilyloxyethyl)-3-p-methoxyphenyl-2-phenylisoxazolidine-4-carboxylate

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Technology Process of benzyl (3R*,4R*,5R*)-5-(2'-tert-butyldimethylsilyloxyethyl)-3-p-methoxyphenyl-2-phenylisoxazolidine-4-carboxylate

There total 5 articles about benzyl (3R*,4R*,5R*)-5-(2'-tert-butyldimethylsilyloxyethyl)-3-p-methoxyphenyl-2-phenylisoxazolidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: 107699-46-7
benzyl (3R*,4R*,5R*)-5-(2'-tert-butyldimethylsilyloxyethyl)-3-p-methoxyphenyl-2-phenylisoxazolidine-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) aq. KOH, 2.) 18-crown-6 / 1.) dioxane, RT, overnight, 2.) DMF,

2: 85 percent / NaIO₄ / H₂O / 48 h / Ambient temperature

3: NaBH₃CN, aq. HCl / methanol / 1 h

4: imidazole / dimethylformamide / Ambient temperature

With 1H-imidazole; hydrogenchloride; potassium hydroxide; sodium periodate; 18-crown-6 ether; sodium cyanoborohydride; In methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 102972-08-7
(3R*,3aR*,6S*,7aR*)-6-acetoxymethyl-3-p-methoxyphenyl-4-oxo-2-phenyl-tetrahydropyrano-<3,4-d>-isoxazolidine

: 107699-46-7
benzyl (3R*,4R*,5R*)-5-(2'-tert-butyldimethylsilyloxyethyl)-3-p-methoxyphenyl-2-phenylisoxazolidine-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) aq. KOH, 2.) 18-crown-6 / 1.) dioxane, RT, overnight, 2.) DMF,

2: 85 percent / NaIO₄ / H₂O / 48 h / Ambient temperature

3: NaBH₃CN, aq. HCl / methanol / 1 h

4: imidazole / dimethylformamide / Ambient temperature

With 1H-imidazole; hydrogenchloride; potassium hydroxide; sodium periodate; 18-crown-6 ether; sodium cyanoborohydride; In methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 107699-44-5
benzyl (3R*,4R*,5R*)-5-(2'-oxoethyl)-3-p-methoxyphenyl-2-phenylisoxazolidine-4-carboxylate

: 107699-46-7
benzyl (3R*,4R*,5R*)-5-(2'-tert-butyldimethylsilyloxyethyl)-3-p-methoxyphenyl-2-phenylisoxazolidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: NaBH₃CN, aq. HCl / methanol / 1 h

2: imidazole / dimethylformamide / Ambient temperature

With 1H-imidazole; hydrogenchloride; sodium cyanoborohydride; In methanol; N,N-dimethyl-formamide;