benzyl 4-chloro-7-methyl-5-(1-methylethoxy)-2-(methylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

Base Information

Chemical Name:benzyl 4-chloro-7-methyl-5-(1-methylethoxy)-2-(methylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate
CAS No.:1269119-34-7
Molecular Formula:C₁₉H₂₀ClN₃O₃S
Molecular Weight:405.905
Hs Code.:

Synonyms:benzyl 4-chloro-7-methyl-5-(1-methylethoxy)-2-(methylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

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Chemical Property of benzyl 4-chloro-7-methyl-5-(1-methylethoxy)-2-(methylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

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Technology Process of benzyl 4-chloro-7-methyl-5-(1-methylethoxy)-2-(methylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

There total 4 articles about benzyl 4-chloro-7-methyl-5-(1-methylethoxy)-2-(methylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 2973-10-6
diisopropyl sulfate

: 1269119-30-3
benzyl 4-chloro-5-hydroxy-7-methyl-2-(methylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

: 1269119-34-7
benzyl 4-chloro-7-methyl-5-(1-methylethoxy)-2-(methylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; acetone; for 4h; Reflux;

Reference yield:

: 313339-35-4
4,6-dichloro-2-(methylsulfanyl)pyrimidine-5-carboxylic acid

: 1269119-34-7
benzyl 4-chloro-7-methyl-5-(1-methylethoxy)-2-(methylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 1 h / 10 - 35 °C

2: triethylamine / 2 h / 10 - 35 °C

3: triethylamine / tetrahydrofuran / 10 - 35 °C

4: potassium tert-butylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 10 - 35 °C

5: potassium carbonate / N,N-dimethyl-formamide; acetone / 4 h / Reflux

With oxalyl dichloride; potassium tert-butylate; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 33097-11-9
4,6-dichloro-2-methylsulfanylpyrimidine-5-carboxyaldehyde

: 1269119-34-7
benzyl 4-chloro-7-methyl-5-(1-methylethoxy)-2-(methylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: aminosulfonic acid; sodium chlorite / water; tert-butyl alcohol; tetrahydrofuran / 0.17 h / -10 - 35 °C

2: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 1 h / 10 - 35 °C

3: triethylamine / 2 h / 10 - 35 °C

4: triethylamine / tetrahydrofuran / 10 - 35 °C

5: potassium tert-butylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 10 - 35 °C

6: potassium carbonate / N,N-dimethyl-formamide; acetone / 4 h / Reflux

With sodium chlorite; oxalyl dichloride; aminosulfonic acid; potassium tert-butylate; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone; toluene; tert-butyl alcohol;