benzyl 7-methyl-5-(1-methylethoxy)-2-(methylsulfanyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

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Chemical Name:benzyl 7-methyl-5-(1-methylethoxy)-2-(methylsulfanyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxylate
CAS No.:1269119-37-0
Molecular Formula:C₁₉H₂₁N₃O₄S
Molecular Weight:387.459
Hs Code.:

Synonyms:benzyl 7-methyl-5-(1-methylethoxy)-2-(methylsulfanyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

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Chemical Property of benzyl 7-methyl-5-(1-methylethoxy)-2-(methylsulfanyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

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Technology Process of benzyl 7-methyl-5-(1-methylethoxy)-2-(methylsulfanyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

There total 3 articles about benzyl 7-methyl-5-(1-methylethoxy)-2-(methylsulfanyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1269119-34-7
benzyl 4-chloro-7-methyl-5-(1-methylethoxy)-2-(methylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

: 1269119-37-0
benzyl 7-methyl-5-(1-methylethoxy)-2-(methylsulfanyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

Guidance literature:: With sodium acetate; In dimethyl sulfoxide; at 100 ℃; for 5h;

Reference yield:

: 313339-35-4
4,6-dichloro-2-(methylsulfanyl)pyrimidine-5-carboxylic acid

: 1269119-37-0
benzyl 7-methyl-5-(1-methylethoxy)-2-(methylsulfanyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 1 h / 10 - 35 °C

2: triethylamine / 2 h / 10 - 35 °C

3: triethylamine / tetrahydrofuran / 10 - 35 °C

4: potassium tert-butylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 10 - 35 °C

5: potassium carbonate / N,N-dimethyl-formamide; acetone / 4 h / Reflux

6: sodium acetate / dimethyl sulfoxide / 5 h / 100 °C

With oxalyl dichloride; potassium tert-butylate; sodium acetate; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 33097-11-9
4,6-dichloro-2-methylsulfanylpyrimidine-5-carboxyaldehyde

: 1269119-37-0
benzyl 7-methyl-5-(1-methylethoxy)-2-(methylsulfanyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: aminosulfonic acid; sodium chlorite / water; tert-butyl alcohol; tetrahydrofuran / 0.17 h / -10 - 35 °C

2: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 1 h / 10 - 35 °C

3: triethylamine / 2 h / 10 - 35 °C

4: triethylamine / tetrahydrofuran / 10 - 35 °C

5: potassium tert-butylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 10 - 35 °C

6: potassium carbonate / N,N-dimethyl-formamide; acetone / 4 h / Reflux

7: sodium acetate / dimethyl sulfoxide / 5 h / 100 °C

With sodium chlorite; oxalyl dichloride; aminosulfonic acid; potassium tert-butylate; sodium acetate; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; toluene; tert-butyl alcohol;