methyl 3-cyclohexyl-1-(2-hydroxyethyl)-2-(2-hydroxypyridin-3-yl)-1H-indole-6-carboxylate

Base Information

Chemical Name:methyl 3-cyclohexyl-1-(2-hydroxyethyl)-2-(2-hydroxypyridin-3-yl)-1H-indole-6-carboxylate
CAS No.:877280-21-2
Molecular Formula:C₂₃H₂₆N₂O₄
Molecular Weight:394.47
Hs Code.:

Synonyms:methyl 3-cyclohexyl-1-(2-hydroxyethyl)-2-(2-hydroxypyridin-3-yl)-1H-indole-6-carboxylate

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Chemical Property of methyl 3-cyclohexyl-1-(2-hydroxyethyl)-2-(2-hydroxypyridin-3-yl)-1H-indole-6-carboxylate

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Technology Process of methyl 3-cyclohexyl-1-(2-hydroxyethyl)-2-(2-hydroxypyridin-3-yl)-1H-indole-6-carboxylate

There total 6 articles about methyl 3-cyclohexyl-1-(2-hydroxyethyl)-2-(2-hydroxypyridin-3-yl)-1H-indole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 877280-14-3
methyl 1-(2-(benzyloxy)ethyl)-2-(2-(benzyloxy)pyridin-3-yl)-3-cyclohexyl-1H-indole-6-carboxylate

: 877280-21-2
methyl 3-cyclohexyl-1-(2-hydroxyethyl)-2-(2-hydroxypyridin-3-yl)-1H-indole-6-carboxylate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; for 72h; under 760.051 Torr;

Reference yield: 90.0%

: 877280-14-3
methyl 1-(2-(benzyloxy)ethyl)-2-(2-(benzyloxy)pyridin-3-yl)-3-cyclohexyl-1H-indole-6-carboxylate

: 877280-21-2
C₂₃H₂₆N₂O₄

Guidance literature:: With palladium on activated charcoal; hydrogen;
DOI:10.1016/j.bmcl.2012.02.063

Reference yield:

: 863579-14-0
3-cyclohexyl-2-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)-1H-indole-6-carboxylic acid methyl ester

: 877280-21-2
C₂₃H₂₆N₂O₄

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; lithium chloride / ethanol; toluene / 80 °C

2: sodium hydride / N,N-dimethyl-formamide

3: palladium on activated charcoal; hydrogen

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; hydrogen; sodium hydride; sodium carbonate; lithium chloride; In ethanol; N,N-dimethyl-formamide; toluene; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2012.02.063