methyl 2-(2-(benzyloxy)pyridin-3-yl)-3-cyclohexyl-1H-indole-6-carboxylate

Base Information

Chemical Name:methyl 2-(2-(benzyloxy)pyridin-3-yl)-3-cyclohexyl-1H-indole-6-carboxylate
CAS No.:877280-06-3
Molecular Formula:C28H28N2O3
Molecular Weight:440.542
Hs Code.:

Synonyms:methyl 2-(2-(benzyloxy)pyridin-3-yl)-3-cyclohexyl-1H-indole-6-carboxylate

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Chemical Property of methyl 2-(2-(benzyloxy)pyridin-3-yl)-3-cyclohexyl-1H-indole-6-carboxylate

Chemical Property:

PSA：64.21000
LogP:6.64320

Purity/Quality:

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Technology Process of methyl 2-(2-(benzyloxy)pyridin-3-yl)-3-cyclohexyl-1H-indole-6-carboxylate

There total 3 articles about methyl 2-(2-(benzyloxy)pyridin-3-yl)-3-cyclohexyl-1H-indole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 863579-14-0
3-cyclohexyl-2-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)-1H-indole-6-carboxylic acid methyl ester

: 52200-49-4
3-bromo-2-(phenylmethoxy)pyridine

: 877280-06-3
methyl 2-(2-(benzyloxy)pyridin-3-yl)-3-cyclohexyl-1H-indole-6-carboxylate

Guidance literature:: With sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 80 ℃; for 6h;

Reference yield:

: 13466-43-8
3-bromo-pyridin-2-ol

: 877280-06-3
methyl 2-(2-(benzyloxy)pyridin-3-yl)-3-cyclohexyl-1H-indole-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; lithium chloride / ethanol; toluene / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium carbonate; lithium chloride; In ethanol; N,N-dimethyl-formamide; toluene; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2012.02.063

Reference yield:

: 100-39-0
benzyl bromide

: 877280-06-3
methyl 2-(2-(benzyloxy)pyridin-3-yl)-3-cyclohexyl-1H-indole-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; lithium chloride / ethanol; toluene / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium carbonate; lithium chloride; In ethanol; N,N-dimethyl-formamide; toluene; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2012.02.063