3-<1-methyl-4-<1-methyl-4-(1-methyl-4-aminopyrrole-2-carboxamido)pyrrole-2-carboxamido>pyrrole-2-carboxamido>propionitrile

Base Information

Chemical Name:3-<1-methyl-4-<1-methyl-4-(1-methyl-4-aminopyrrole-2-carboxamido)pyrrole-2-carboxamido>pyrrole-2-carboxamido>propionitrile
CAS No.:121541-72-8
Molecular Formula:C₂₁H₂₄N₈O₃
Molecular Weight:436.473
Hs Code.:

Synonyms:3-<1-methyl-4-<1-methyl-4-(1-methyl-4-aminopyrrole-2-carboxamido)pyrrole-2-carboxamido>pyrrole-2-carboxamido>propionitrile

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Chemical Property of 3-<1-methyl-4-<1-methyl-4-(1-methyl-4-aminopyrrole-2-carboxamido)pyrrole-2-carboxamido>pyrrole-2-carboxamido>propionitrile

Chemical Property:

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MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-<1-methyl-4-<1-methyl-4-(1-methyl-4-aminopyrrole-2-carboxamido)pyrrole-2-carboxamido>pyrrole-2-carboxamido>propionitrile

There total 1 articles about 3-<1-methyl-4-<1-methyl-4-(1-methyl-4-aminopyrrole-2-carboxamido)pyrrole-2-carboxamido>pyrrole-2-carboxamido>propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 77716-11-1
4-[(tert-butoxycarbonyl)amino]-1-methyl-1H-pyrrole-2-carboxylic acid

: 121541-72-8
3-<1-methyl-4-<1-methyl-4-(1-methyl-4-aminopyrrole-2-carboxamido)pyrrole-2-carboxamido>pyrrole-2-carboxamido>propionitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 4.3 mg / EDCI; DMAP / dimethylformamide / 16 h / 25 °C

2: 98 percent / aq. LiOH / tetrahydrofuran; methanol / 8 h / 60 °C

3: EDCI; DMAP / dimethylformamide / 14 h / 25 °C

4: HCl / ethanol / 2.5 h / 0 - 25 °C

With hydrogenchloride; dmap; lithium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ja994192d

Reference yield:

: 1679-64-7
Monomethyl terephthalate

: 121541-72-8
3-<1-methyl-4-<1-methyl-4-(1-methyl-4-aminopyrrole-2-carboxamido)pyrrole-2-carboxamido>pyrrole-2-carboxamido>propionitrile

: 288623-90-5
N-(5-{5-[5-(2-cyano-ethylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-1-methyl-1H-pyrrol-3-ylcarbamoyl}-1-methyl-1H-pyrrol-3-yl)-terephthalamic acid methyl ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1002/1099-0690(200006)2000:11<2095::AID-EJOC2095>3.0.CO;2-J

Reference yield:

: 121541-72-8
3-<1-methyl-4-<1-methyl-4-(1-methyl-4-aminopyrrole-2-carboxamido)pyrrole-2-carboxamido>pyrrole-2-carboxamido>propionitrile

: 288623-95-0
N-(5-{5-[5-(2-cyano-ethylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-1-methyl-1H-pyrrol-3-ylcarbamoyl}-1-methyl-1H-pyrrol-3-yl)-terephthalamic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1-hydroxybenzotriazole; 1,3-dicyclohexylcarbodiimide / dimethylformamide / 18 h / 20 °C

2: 80 percent / sodium hydroxide; water / 18 h / Heating

With sodium hydroxide; water; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; 1: Condensation / 2: Hydrolysis;
DOI:10.1002/1099-0690(200006)2000:11<2095::AID-EJOC2095>3.0.CO;2-J