tert-butyl 4-((2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-((2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazine-1-carboxylate
CAS No.:885617-10-7
Molecular Formula:C₂₆H₃₃N₅O₄S
Molecular Weight:511.645
Hs Code.:

Synonyms:tert-butyl 4-((2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazine-1-carboxylate

Suppliers and Price of tert-butyl 4-((2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-((2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazine-1-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl 4-((2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazine-1-carboxylate

There total 6 articles about tert-butyl 4-((2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 885699-79-6
4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazine-1-carboxylic acid tert-butyl ester

: 87199-18-6
3-hydroxyphenylboronic acid

: 885617-10-7
tert-butyl 4-((2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazine-1-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; at 120 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm3008745

Reference yield:

: 885618-31-5
2-chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde

: 885617-10-7
tert-butyl 4-((2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / 1,2-dichloro-ethane / 2 h / 20 °C

1.2: 10 h / 20 °C

2.1: sodium carbonate / toluene; ethanol; water / 1 h / 120 °C / Inert atmosphere; Sealed vial

With sodium carbonate; acetic acid; In ethanol; water; 1,2-dichloro-ethane; toluene; 2.1: Suzuki Coupling;

Reference yield:

: 16234-14-3
2,4-dichlorothieno[3,2-d]pyrimidine

: 885617-10-7
tert-butyl 4-((2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol / 1 h / 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

2.2: 2 h / -78 - 20 °C

3.1: acetic acid / 1,2-dichloro-ethane / 2 h / 20 °C

3.2: 10 h / 20 °C

4.1: sodium carbonate / toluene; ethanol; water / 1 h / 120 °C / Inert atmosphere; Sealed vial

With sodium carbonate; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; water; 1,2-dichloro-ethane; toluene; 4.1: Suzuki Coupling;