(E)-tert-butyl 4-(6-(4-((2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-3,6-dioxohex-1-enyl)benzylcarbamate

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Chemical Name:(E)-tert-butyl 4-(6-(4-((2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-3,6-dioxohex-1-enyl)benzylcarbamate
CAS No.:1276109-97-7
Molecular Formula:C₃₉H₄₆N₆O₆S
Molecular Weight:726.897
Hs Code.:

Synonyms:(E)-tert-butyl 4-(6-(4-((2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-3,6-dioxohex-1-enyl)benzylcarbamate

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Chemical Property of (E)-tert-butyl 4-(6-(4-((2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-3,6-dioxohex-1-enyl)benzylcarbamate

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Technology Process of (E)-tert-butyl 4-(6-(4-((2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-3,6-dioxohex-1-enyl)benzylcarbamate

There total 7 articles about (E)-tert-butyl 4-(6-(4-((2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-3,6-dioxohex-1-enyl)benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1276109-96-6
diethyl (5-(4-((2-(3-hydroxyphenyl)-4-morpholinothieno-[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2,5-dioxopentyl)phosphonate

: 156866-52-3
tert-butyl N-(4-formylbenzyl)carbamate

: 1276109-97-7
(E)-tert-butyl 4-(6-(4-((2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-3,6-dioxohex-1-enyl)benzylcarbamate

Guidance literature:: With potassium carbonate; In N,N-dimethyl acetamide; water; at 70 ℃; for 4h;

Reference yield:

: 885699-79-6
4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazine-1-carboxylic acid tert-butyl ester

: 1276109-97-7
(E)-tert-butyl 4-(6-(4-((2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-3,6-dioxohex-1-enyl)benzylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; toluene; ethanol / 1 h / 120 °C / Inert atmosphere

2.1: hydrogenchloride; methanol / dichloromethane; 1,4-dioxane / 3 h / 20 °C

3.1: 1,1'-carbonyldiimidazole / N,N-dimethyl acetamide; acetonitrile / 0.5 h / 20 °C

3.2: 0.5 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl acetamide; water / 4 h / 70 °C

With hydrogenchloride; methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; 1,1'-carbonyldiimidazole; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl acetamide; water; toluene; acetonitrile; 1.1: |Suzuki Coupling / 4.1: |Wittig-Horner Reaction;
DOI:10.1021/jm3008745

Reference yield:

: 885618-31-5
2-chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde

: 1276109-97-7
(E)-tert-butyl 4-(6-(4-((2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-3,6-dioxohex-1-enyl)benzylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid / 1,2-dichloro-ethane / 2 h / 20 °C

2.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 10 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; toluene; ethanol / 1 h / 120 °C / Inert atmosphere

4.1: hydrogenchloride; methanol / dichloromethane; 1,4-dioxane / 3 h / 20 °C

5.1: 1,1'-carbonyldiimidazole / N,N-dimethyl acetamide; acetonitrile / 0.5 h / 20 °C

5.2: 0.5 h / 20 °C

6.1: potassium carbonate / N,N-dimethyl acetamide; water / 4 h / 70 °C

With hydrogenchloride; methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium tris(acetoxy)borohydride; sodium carbonate; potassium carbonate; acetic acid; 1,1'-carbonyldiimidazole; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl acetamide; water; 1,2-dichloro-ethane; toluene; acetonitrile; 3.1: |Suzuki Coupling / 6.1: |Wittig-Horner Reaction;
DOI:10.1021/jm3008745