4-(hydroxyl(1-(methylsulfonyl)piperidin-4-yl)methyl)-N-isobutyl-N-(2-(trifluoromethyl)benzyl)benzenesulfonamide

Base Information

Chemical Name:4-(hydroxyl(1-(methylsulfonyl)piperidin-4-yl)methyl)-N-isobutyl-N-(2-(trifluoromethyl)benzyl)benzenesulfonamide
CAS No.:1613303-91-5
Molecular Formula:C₂₅H₃₃F₃N₂O₅S₂
Molecular Weight:562.675
Hs Code.:

Synonyms:4-(hydroxyl(1-(methylsulfonyl)piperidin-4-yl)methyl)-N-isobutyl-N-(2-(trifluoromethyl)benzyl)benzenesulfonamide

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Chemical Property of 4-(hydroxyl(1-(methylsulfonyl)piperidin-4-yl)methyl)-N-isobutyl-N-(2-(trifluoromethyl)benzyl)benzenesulfonamide

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Technology Process of 4-(hydroxyl(1-(methylsulfonyl)piperidin-4-yl)methyl)-N-isobutyl-N-(2-(trifluoromethyl)benzyl)benzenesulfonamide

There total 6 articles about 4-(hydroxyl(1-(methylsulfonyl)piperidin-4-yl)methyl)-N-isobutyl-N-(2-(trifluoromethyl)benzyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: 1613303-90-4
N-isobutyl-4-(1-methanesulfonylpiperidin-4-ylidenemethyl)-N-(2-trifluoromethylbenzyl)benzenesulfonamide

: 1613303-91-5
4-(hydroxyl(1-(methylsulfonyl)piperidin-4-yl)methyl)-N-isobutyl-N-(2-(trifluoromethyl)benzyl)benzenesulfonamide

Guidance literature:: N-isobutyl-4-(1-methanesulfonylpiperidin-4-ylidenemethyl)-N-(2-trifluoromethylbenzyl)benzenesulfonamide; With borane-THF; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; ethanol; water; at 0 ℃; for 1h;

Reference yield:

: 66176-39-4
4-(bromomethyl)benzene-1-sulfonyl chloride

: 1613303-91-5
4-(hydroxyl(1-(methylsulfonyl)piperidin-4-yl)methyl)-N-isobutyl-N-(2-(trifluoromethyl)benzyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / dichloromethane / 1.5 h / 20 °C

2.1: triphenylphosphine / toluene / 18 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

3.2: 18 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 110 °C

5.1: borane-THF / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

5.2: 1 h / 0 °C

With pyridine; borane-THF; sodium hydride; potassium carbonate; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1308718-72-0
4-(bromomethyl)-N-(isobutyl)benzenesulfonamide

: 1613303-91-5
4-(hydroxyl(1-(methylsulfonyl)piperidin-4-yl)methyl)-N-isobutyl-N-(2-(trifluoromethyl)benzyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine / toluene / 18 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

2.2: 18 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 110 °C

4.1: borane-THF / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

4.2: 1 h / 0 °C

With borane-THF; sodium hydride; potassium carbonate; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; mineral oil;