N-isobutyl-4-(1-methanesulfonylpiperidin-4-ylidenemethyl)-N-(2-trifluoromethylbenzyl)benzenesulfonamide

Base Information

Chemical Name:N-isobutyl-4-(1-methanesulfonylpiperidin-4-ylidenemethyl)-N-(2-trifluoromethylbenzyl)benzenesulfonamide
CAS No.:1613303-90-4
Molecular Formula:C₂₅H₃₁F₃N₂O₄S₂
Molecular Weight:544.659
Hs Code.:

Synonyms:N-isobutyl-4-(1-methanesulfonylpiperidin-4-ylidenemethyl)-N-(2-trifluoromethylbenzyl)benzenesulfonamide

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Chemical Property of N-isobutyl-4-(1-methanesulfonylpiperidin-4-ylidenemethyl)-N-(2-trifluoromethylbenzyl)benzenesulfonamide

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Technology Process of N-isobutyl-4-(1-methanesulfonylpiperidin-4-ylidenemethyl)-N-(2-trifluoromethylbenzyl)benzenesulfonamide

There total 5 articles about N-isobutyl-4-(1-methanesulfonylpiperidin-4-ylidenemethyl)-N-(2-trifluoromethylbenzyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 395-44-8
o-trifluoromethylbenzyl bromide

: 1613304-95-2
N-isobutyl-4-(1-methanesulfonylpiperidin-4-ylidenemethyl)benzenesulfonamide

: 1613303-90-4
N-isobutyl-4-(1-methanesulfonylpiperidin-4-ylidenemethyl)-N-(2-trifluoromethylbenzyl)benzenesulfonamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 6h;

Reference yield:

: 1308718-72-0
4-(bromomethyl)-N-(isobutyl)benzenesulfonamide

: 1613303-90-4
N-isobutyl-4-(1-methanesulfonylpiperidin-4-ylidenemethyl)-N-(2-trifluoromethylbenzyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine / toluene / 18 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

2.2: 18 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 110 °C

With sodium hydride; potassium carbonate; triphenylphosphine; In N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 66176-39-4
4-(bromomethyl)benzene-1-sulfonyl chloride

: 1613303-90-4
N-isobutyl-4-(1-methanesulfonylpiperidin-4-ylidenemethyl)-N-(2-trifluoromethylbenzyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane / 1.5 h / 20 °C

2.1: triphenylphosphine / toluene / 18 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

3.2: 18 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 110 °C

With pyridine; sodium hydride; potassium carbonate; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;