N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2-nitrobenzoylamine

Base Information

Chemical Name:N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2-nitrobenzoylamine
CAS No.:206874-91-1
Molecular Formula:C₂₆H₂₇N₃O₅
Molecular Weight:461.517
Hs Code.:

Synonyms:N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2-nitrobenzoylamine

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Chemical Property of N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2-nitrobenzoylamine

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Technology Process of N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2-nitrobenzoylamine

There total 2 articles about N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2-nitrobenzoylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 82925-02-8
4-<2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolyl)ethyl>benzenamine

: 610-14-0
2-nitrobenzyl chloride

: 206874-91-1
N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2-nitrobenzoylamine

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 48h;
DOI:10.1016/j.bmc.2009.01.072

Reference yield:

: 552-16-9,104810-18-6
ortho-nitrobenzoic acid

: 206874-91-1
N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2-nitrobenzoylamine

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / N,N-dimethyl-formamide / 2 h / 83 °C

2: sodium hydrogencarbonate / dichloromethane / 5 h / 0 - 20 °C

With thionyl chloride; sodium hydrogencarbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2015.06.049

Reference yield: 89.0%

: 206874-91-1
N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2-nitrobenzoylamine

: 206874-57-9
(N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl))ethyl)phenyl)-2-aminobenzamide

Guidance literature:: With palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃; for 24h; under 3000.3 Torr;
DOI:10.1016/j.bmc.2009.01.072